Technology Process of 6-phenyl-7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone
There total 5 articles about 6-phenyl-7-(phenylthio)-1,2,3,5,8,8a-hexahydro-5-indolizinone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
toluene;
at 140 ℃;
for 48h;
Sealed tube;
DOI:10.1021/jo102092b
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-Bromosuccinimide / acetonitrile / 2 h / Reflux; Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene / 48 h / 140 °C / Sealed tube
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
toluene; acetonitrile;
2: Suzuki coupling;
DOI:10.1021/jo102092b
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydrogencarbonate; hydroquinone / toluene / 4.5 h / 110 °C / Inert atmosphere
2: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 2 h / Inert atmosphere; Reflux
3: sodium hydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux
4: N-Bromosuccinimide / acetonitrile / 2 h / Reflux; Inert atmosphere
5: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene / 48 h / 140 °C / Sealed tube
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; hydroquinone;
In
tetrahydrofuran; toluene; acetonitrile;
5: Suzuki coupling;
DOI:10.1021/jo102092b
