8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE

Base Information

• Chemical Name: 8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE
• CAS No.: 707-17-5
• Molecular Formula: C₉H₁₄N₂O₂
• Molecular Weight: 182.222
• Hs Code.: 2933990090
• Mol file: 707-17-5.mol

Synonyms:8-methyl-2,4-diazaspiro[4.5]decane-1,3-dione;3-Methylcyclohexanespiro-5'-hydantoin;1,3-DIAZASPIRO(4.5)DECANE-2,4-DIONE,8-METHYL;1,4-dione,8-methyl;8-methyl-1,3-diaza-spiro[4.5]decane-2,4-dione;

Chemical Property of 8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE

Chemical Property:

• Melting Point: 278 °C (water)
• PSA: 58.20000
• Density: 1.2g/cm³
• LogP: 1.43230

Purity/Quality:

97% ^*data from raw suppliers

8-Methyl-1,3-diazaspiro[4.5]decane-2,4-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE

There total 5 articles about 8-METHYL-1,3-DIAZASPIRO[4.5]DECANE-2,4-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

potassium cyanide + ammonium carbonate (506-87-6,6721-33-1,10361-29-2) + 1-methylcyclohexan-4-one (589-92-4) → 8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione (88809-35-2,707-17-5)

Guidance literature:

In ethanol; water; at 55 - 60 ℃;

DOI:10.1007/s00706-011-0600-9

Reference yield:

potassium cyanide (151-50-8) + 1-methylcyclohexan-4-one (589-92-4) → 8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione (88809-35-2,707-17-5)

Guidance literature:

With ammonium carbonate; In ethanol; at 55 - 60 ℃;

DOI:10.1021/ja962905b

Reference yield:

2,2,2-trifluoroethyl carbamate (461-37-0) + methyl 1-amino-4-methylcyclohexanecarboxylate → 8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione (88809-35-2,707-17-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 100 ℃; for 4h; Sealed tube;

DOI:10.1021/acscombsci.7b00163

upstream raw materials:

potassium cyanide

1-methylcyclohexan-4-one

ammonium carbonate

2,2,2-trifluoroethyl carbamate

Downstream raw materials:

1-amino-4-methyl-cyclohexanecarboxylic acid

1-tert-Butoxycarbonylamino-4-methyl-cyclohexanecarboxylic acid

1-[(1-tert-Butoxycarbonylamino-4-methyl-cyclohexanecarbonyl)-amino]-4-methyl-cyclohexanecarboxylic acid methyl ester

3-[(9,10-dihydro-9,10-dioxo-2-anthracenyl)sulfonyl]-8-methyl-1,3-diazaspiro[4.5]decane-2,4-dione

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