1-(4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzyl)-3-[4-(4-nitrophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]urea

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Chemical Name:1-(4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzyl)-3-[4-(4-nitrophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]urea
CAS No.:850148-57-1
Molecular Formula:C₂₅H₂₉N₅O₈
Molecular Weight:527.534
Hs Code.:

Synonyms:1-(4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzyl)-3-[4-(4-nitrophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]urea

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Chemical Property of 1-(4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzyl)-3-[4-(4-nitrophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]urea

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Technology Process of 1-(4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzyl)-3-[4-(4-nitrophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]urea

There total 7 articles about 1-(4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzyl)-3-[4-(4-nitrophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 6-(p-nitrophenyl)isocytosine

: 850148-56-0
1-isocyanatomethyl-4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzene

: 850148-57-1
1-(4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzyl)-3-[4-(4-nitrophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]urea

Guidance literature:: With pyridine; for 18h; Heating;
DOI:10.1021/jo048223l

Reference yield:

: 72593-77-2,92450-98-1
3,6,9-trioxadecyl bromide

: 850148-57-1
1-(4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzyl)-3-[4-(4-nitrophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]urea

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / K₂CO₃ / acetonitrile / 18 h / Heating

2: 69 percent / NaOH / methanol; H₂O / 3 h / Heating

3: SOCl₂ / CH₂Cl₂ / 18 h / Heating

4: NaN₃ / acetone; H₂O / 0.5 h / 5 °C

5: toluene / 0.5 h / Heating

6: 81 percent / pyridine / 18 h / Heating

With pyridine; sodium hydroxide; thionyl chloride; sodium azide; potassium carbonate; In methanol; dichloromethane; water; acetone; toluene; acetonitrile; 5: Curtius rearrangement;
DOI:10.1021/jo048223l

Reference yield:

: 850148-61-7
(4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}phenyl)acetyl chloride

: 850148-57-1
1-(4-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzyl)-3-[4-(4-nitrophenyl)-6-oxo-1,6-dihydropyrimidin-2-yl]urea

Guidance literature:: Multi-step reaction with 3 steps

1: NaN₃ / acetone; H₂O / 0.5 h / 5 °C

2: toluene / 0.5 h / Heating

3: 81 percent / pyridine / 18 h / Heating

With pyridine; sodium azide; In water; acetone; toluene; 2: Curtius rearrangement;
DOI:10.1021/jo048223l