[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-acetic acid

Base Information

Chemical Name:[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-acetic acid
CAS No.:471903-69-2
Molecular Formula:C₂₀H₁₉ClF₂O₄S
Molecular Weight:428.884
Hs Code.:

Synonyms:[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-acetic acid

Suppliers and Price of [4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of [4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-acetic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-acetic acid

There total 8 articles about [4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 471903-67-0
[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-acetic acid ethyl ester

: 471903-69-2
[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-acetic acid

Guidance literature:: With lithium hydroxide; In ethanol; at 20 ℃; for 5h;

Reference yield:

: 471903-20-5
4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanone

: 471903-69-2
[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran

2: L-selectride / tetrahydrofuran / -40 °C

3: aq. LiOH / methanol

With lithium hydroxide; L-Selectride; sodium hydride; In tetrahydrofuran; methanol; 1: Wadsworth-Horner-Emmons reaction;
DOI:10.1016/j.bmcl.2005.10.009

Reference yield:

: 471903-66-9
[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexylidene]-acetic acid ethyl ester

: 471903-69-2
[4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: L-selectride / tetrahydrofuran / -40 °C

2: aq. LiOH / methanol

With lithium hydroxide; L-Selectride; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2005.10.009