(3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoic acid

Base Information

Chemical Name:(3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoic acid
CAS No.:1202575-66-3
Molecular Formula:C₂₀H₂₁ClO₄
Molecular Weight:360.837
Hs Code.:

Synonyms:(3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoic acid

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Chemical Property of (3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoic acid

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Technology Process of (3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoic acid

There total 15 articles about (3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: methyl (3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoate

: 1202575-66-3
(3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; water; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2015.07.028

Reference yield: 85.0%

: 1202577-80-7
(3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropan-1-ol

: 1202575-66-3
(3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoic acid

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; In acetonitrile; at 0 ℃; for 2h;

Reference yield:

: 705939-73-7
methyl 3-[4-(benzyloxy)phenyl]-3-oxopropanoate

: 1202575-66-3
(3S)-3-(4-{[(1R)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; formic acid / 0 - 35 °C / Inert atmosphere

1.2: 2 h / 35 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

5.1: hydrogen / Raney nickel / tetrahydrofuran / 14 h / 20 °C

6.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

7.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite / acetonitrile / 2 h / 0 °C

With 1H-imidazole; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; lithium aluminium tetrahydride; formic acid; hydrogen; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; Raney nickel; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile;