2-Benzyl-3-(tert-butoxycarbonyl-isopropyl-amino)-propionic acid methyl ester

Base Information

• Chemical Name: 2-Benzyl-3-(tert-butoxycarbonyl-isopropyl-amino)-propionic acid methyl ester
• CAS No.: 157055-11-3
• Molecular Formula: C₁₉H₂₉NO₄
• Molecular Weight: 335.444
• Mol file: 157055-11-3.mol

Synonyms:2-Benzyl-3-(tert-butoxycarbonyl-isopropyl-amino)-propionic acid methyl ester

Chemical Property of 2-Benzyl-3-(tert-butoxycarbonyl-isopropyl-amino)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzyl-3-(tert-butoxycarbonyl-isopropyl-amino)-propionic acid methyl ester

There total 3 articles about 2-Benzyl-3-(tert-butoxycarbonyl-isopropyl-amino)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-[(tert-Butoxycarbonyl-isopropyl-amino)-methyl]-3-phenyl-acrylic acid methyl ester (157055-05-5) → 2-Benzyl-3-(tert-butoxycarbonyl-isopropyl-amino)-propionic acid methyl ester (157055-11-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 0.333333h; under 760 Torr;

DOI:10.1080/00397919408011492

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-Benzyl-3-(tert-butoxycarbonyl-isopropyl-amino)-propionic acid methyl ester (157055-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NaOH / CH₂Cl₂ / 12 h / 10 °C

2: H₂ / 10percent Pd/C / ethanol / 0.33 h / 760 Torr

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1080/00397919408011492

Reference yield:

methyl (E)-2-<(isopropylamino)methyl>-phenylprop-2-enoate (124957-47-7) → 2-Benzyl-3-(tert-butoxycarbonyl-isopropyl-amino)-propionic acid methyl ester (157055-11-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NaOH / CH₂Cl₂ / 12 h / 10 °C

2: H₂ / 10percent Pd/C / ethanol / 0.33 h / 760 Torr

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1080/00397919408011492

upstream raw materials:

(E)-2-[(tert-Butoxycarbonyl-isopropyl-amino)-methyl]-3-phenyl-acrylic acid methyl ester

di-tert-butyl dicarbonate

methyl (E)-2-<(isopropylamino)methyl>-phenylprop-2-enoate