3-(5-(4-chlorophenyl)-1-(6-methoxypyridazin-3-yl)-1Hpyrazol-3-yl)-1-(piperidin-1-yl)propan-1-one

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Chemical Name:3-(5-(4-chlorophenyl)-1-(6-methoxypyridazin-3-yl)-1Hpyrazol-3-yl)-1-(piperidin-1-yl)propan-1-one
CAS No.:1443777-99-8
Molecular Formula:C₂₂H₂₄ClN₅O₂
Molecular Weight:425.918
Hs Code.:

Synonyms:3-(5-(4-chlorophenyl)-1-(6-methoxypyridazin-3-yl)-1Hpyrazol-3-yl)-1-(piperidin-1-yl)propan-1-one

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Chemical Property of 3-(5-(4-chlorophenyl)-1-(6-methoxypyridazin-3-yl)-1Hpyrazol-3-yl)-1-(piperidin-1-yl)propan-1-one

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Technology Process of 3-(5-(4-chlorophenyl)-1-(6-methoxypyridazin-3-yl)-1Hpyrazol-3-yl)-1-(piperidin-1-yl)propan-1-one

There total 3 articles about 3-(5-(4-chlorophenyl)-1-(6-methoxypyridazin-3-yl)-1Hpyrazol-3-yl)-1-(piperidin-1-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 110-89-4
piperidine

: 1087032-91-4
3-(5-(4-chlorophenyl)-1-(6-methoxypyridazin-3-yl)-1H-pyrazol-3-yl)propanoic acid

: 1443777-99-8
3-(5-(4-chlorophenyl)-1-(6-methoxypyridazin-3-yl)-1Hpyrazol-3-yl)-1-(piperidin-1-yl)propan-1-one

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2013.03.048

Reference yield:

: 111881-78-8
6-(4-chlorophenyl)-4,6-dioxohexanoic acid

: 1443777-99-8
3-(5-(4-chlorophenyl)-1-(6-methoxypyridazin-3-yl)-1Hpyrazol-3-yl)-1-(piperidin-1-yl)propan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / Reflux

1.2: Reflux

2.1: sodium methylate / Reflux

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2013.03.048

Reference yield:

: 153708-81-7
3-(5-(4-chlorophenyl)-1-(3-chloropyridazin-6-yl)-3-pyrazolyl]propionic acid

: 1443777-99-8
3-(5-(4-chlorophenyl)-1-(6-methoxypyridazin-3-yl)-1Hpyrazol-3-yl)-1-(piperidin-1-yl)propan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; sodium methylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.ejmech.2013.03.048