4-[2-(2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propoxy]benzaldehyde

Base Information

Chemical Name:4-[2-(2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propoxy]benzaldehyde
CAS No.:582313-64-2
Molecular Formula:C₁₇H₂₂O₅
Molecular Weight:306.359
Hs Code.:

Synonyms:4-[2-(2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propoxy]benzaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2-(2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propoxy]benzaldehyde

Chemical Property:

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Technology Process of 4-[2-(2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propoxy]benzaldehyde

There total 3 articles about 4-[2-(2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propoxy]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 582313-63-1
2-(2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propion-1-ol

: 582313-64-2
4-[2-(2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propoxy]benzaldehyde

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 24h;
DOI:10.1248/cpb.51.276

Reference yield:

: 25581-41-3
D-erythronolactone acetonide

: 582313-64-2
4-[2-(2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propoxy]benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

1.2: toluene / 24 h / 110 °C

1.3: 34.1 percent / potassium t-butoxide / toluene / 3 h / 20 °C

2.1: 98 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

3.1: 97.2 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 24 h

With diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 3.1: Mitsunobu reaction;
DOI:10.1248/cpb.51.276

Reference yield:

: 582313-62-0
2-(2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propionic acid ethyl ester

: 582313-64-2
4-[2-(2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)propoxy]benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

2: 97.2 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 24 h

With diisobutylaluminium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1248/cpb.51.276