(S)-2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-ylamino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Chemical Name:(S)-2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-ylamino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one
CAS No.:1605326-16-6
Molecular Formula:C₂₁H₁₉N₉O
Molecular Weight:413.442
Hs Code.:

Synonyms:(S)-2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-ylamino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Chemical Property of (S)-2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-ylamino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

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Technology Process of (S)-2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-ylamino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

There total 4 articles about (S)-2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-ylamino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 269410-08-4
pyrazole-4-boronic acid pinacol ester

: 1605328-62-8
(S)-2-(1-(6-amino-5-iodopyrimidin-4-ylamino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

: 1605326-16-6
(S)-2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-ylamino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; for 42h; Inert atmosphere;

Reference yield:

: 1403942-30-2
(S)-2-(1-aminoethyl)-3-phenylpyrrolo[1,2-f][1,2,4]triazin-4(3H)-one

: 1605326-16-6
(S)-2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-ylamino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; cesium iodide / tert-butyl alcohol / 40 h / 140 °C / Sealed tube

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 42 h / 80 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; N-ethyl-N,N-diisopropylamine; cesium iodide; In 1,4-dioxane; water; tert-butyl alcohol;

Reference yield:

: 1403942-10-8
1-amino-N-phenyl-1H-pyrrole-2-carboxamide

: 1605326-16-6
(S)-2-(1-(6-amino-5-(1H-pyrazol-4-yl)pyrimidin-4-ylamino)ethyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2.1: trichlorophosphate / 6 h / 80 °C

2.2: 80 °C / Sealed tube

3.1: N-ethyl-N,N-diisopropylamine; cesium iodide / tert-butyl alcohol / 40 h / 140 °C / Sealed tube

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 42 h / 80 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; cesium iodide; trichlorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide; tert-butyl alcohol;