2-(5-((bis(4-fluorophenyl)methyl)carbamoyl)-4-hydroxypyrimidine-2-carboxamido)acetic acid

Base Information

Chemical Name:2-(5-((bis(4-fluorophenyl)methyl)carbamoyl)-4-hydroxypyrimidine-2-carboxamido)acetic acid
CAS No.:1428548-30-4
Molecular Formula:C₂₁H₁₆F₂N₄O₅
Molecular Weight:442.379
Hs Code.:

Synonyms:2-(5-((bis(4-fluorophenyl)methyl)carbamoyl)-4-hydroxypyrimidine-2-carboxamido)acetic acid

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Chemical Property of 2-(5-((bis(4-fluorophenyl)methyl)carbamoyl)-4-hydroxypyrimidine-2-carboxamido)acetic acid

Chemical Property:

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Technology Process of 2-(5-((bis(4-fluorophenyl)methyl)carbamoyl)-4-hydroxypyrimidine-2-carboxamido)acetic acid

There total 10 articles about 2-(5-((bis(4-fluorophenyl)methyl)carbamoyl)-4-hydroxypyrimidine-2-carboxamido)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1428548-29-1
ethyl 2-(5-((bis(4-fluorophenyl)methyl)carbamoyl)-4-hydroxypyrimidine-2-carboxamido)acetate

: 1428548-30-4
2-(5-((bis(4-fluorophenyl)methyl)carbamoyl)-4-hydroxypyrimidine-2-carboxamido)acetic acid

Guidance literature:: With water; potassium hydroxide; at 50 ℃; for 0.5h;

Reference yield:

: 1428548-41-7
2-((benzyloxy)methyl)-4-hydroxypyrimidine-5-carboxylic acid

: 1428548-30-4
2-(5-((bis(4-fluorophenyl)methyl)carbamoyl)-4-hydroxypyrimidine-2-carboxamido)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; HATU / acetonitrile / 20 °C

2: palladium on activated charcoal; ammonium formate / methanol / Reflux

3: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

4: sodium chlorite; sodium hydrogenphosphate dodecahydrate / water; tert-butyl alcohol / 4 h / 20 °C

5: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C

6: water; potassium hydroxide / 0.5 h / 50 °C

With sodium chlorite; sodium hydrogenphosphate dodecahydrate; palladium on activated charcoal; water; ammonium formate; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1428548-40-6
ethyl 2-((benzyloxy)methyl)-4-hydroxypyrimidine-5-carboxylate

: 1428548-30-4
2-(5-((bis(4-fluorophenyl)methyl)carbamoyl)-4-hydroxypyrimidine-2-carboxamido)acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: water; potassium hydroxide / 1 h / 70 °C

2: triethylamine; HATU / acetonitrile / 20 °C

3: palladium on activated charcoal; ammonium formate / methanol / Reflux

4: Dess-Martin periodane / dichloromethane / 4 h / 20 °C

5: sodium chlorite; sodium hydrogenphosphate dodecahydrate / water; tert-butyl alcohol / 4 h / 20 °C

6: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C

7: water; potassium hydroxide / 0.5 h / 50 °C

With sodium chlorite; sodium hydrogenphosphate dodecahydrate; palladium on activated charcoal; water; ammonium formate; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In methanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile; tert-butyl alcohol;