(Ss,3R)-2-[(tert-butyldimethylsilyl)oxy]-2-cyano-3-[(4-methylphenyl)sulfinyl]amino-3-phenylpropionitrile

Base Information

Chemical Name:(Ss,3R)-2-[(tert-butyldimethylsilyl)oxy]-2-cyano-3-[(4-methylphenyl)sulfinyl]amino-3-phenylpropionitrile
CAS No.:312329-13-8
Molecular Formula:C₂₃H₂₉N₃O₂SSi
Molecular Weight:439.654
Hs Code.:

Synonyms:(Ss,3R)-2-[(tert-butyldimethylsilyl)oxy]-2-cyano-3-[(4-methylphenyl)sulfinyl]amino-3-phenylpropionitrile

Suppliers and Price of (Ss,3R)-2-[(tert-butyldimethylsilyl)oxy]-2-cyano-3-[(4-methylphenyl)sulfinyl]amino-3-phenylpropionitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (Ss,3R)-2-[(tert-butyldimethylsilyl)oxy]-2-cyano-3-[(4-methylphenyl)sulfinyl]amino-3-phenylpropionitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (Ss,3R)-2-[(tert-butyldimethylsilyl)oxy]-2-cyano-3-[(4-methylphenyl)sulfinyl]amino-3-phenylpropionitrile

There total 1 articles about (Ss,3R)-2-[(tert-butyldimethylsilyl)oxy]-2-cyano-3-[(4-methylphenyl)sulfinyl]amino-3-phenylpropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128302-78-3
α-(tert-butyldimethylsilyloxy)malonitrile

: 350479-90-2
(S,E)-N-benzylidene-4-methylbenzenesulfinamide

: 312329-13-8
(Ss,3R)-2-[(tert-butyldimethylsilyl)oxy]-2-cyano-3-[(4-methylphenyl)sulfinyl]amino-3-phenylpropionitrile

: (Ss,3S)-2-[(tert-butyldimethylsilyl)oxy]-2-cyano-3-[(4-methylphenyl)sulfinyl]amino-3-phenylpropionitrile

Guidance literature:: With boron trifluoride diethyl etherate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/S0022-328X(00)00478-2

Reference yield: 92.0%

: 109-73-9,85404-21-3
N-butylamine

: 312329-13-8
(Ss,3R)-2-[(tert-butyldimethylsilyl)oxy]-2-cyano-3-[(4-methylphenyl)sulfinyl]amino-3-phenylpropionitrile

: 312329-15-0
(Ss,2R)-(-)-N-butyl-2-[(4-methylphenyl)sulfinyl]amino-2-phenylacetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -40 ℃; for 1h;
DOI:10.1016/S0022-328X(00)00478-2

Reference yield:

: 312329-13-8
(Ss,3R)-2-[(tert-butyldimethylsilyl)oxy]-2-cyano-3-[(4-methylphenyl)sulfinyl]amino-3-phenylpropionitrile

: (R)-(-)-N-butyl-2-[(4-methylphenyl)sulfonyl]amino-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / TBAF / tetrahydrofuran / 1 h / -40 °C

2: 99 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 20 °C

With tetrabutyl ammonium fluoride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0022-328X(00)00478-2