tert-butyl-((S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl}-but-3-enyloxy)-diphenyl-silane

Base Information

Chemical Name:tert-butyl-((S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl}-but-3-enyloxy)-diphenyl-silane
CAS No.:849122-85-6
Molecular Formula:C₄₅H₆₂O₅Si
Molecular Weight:711.07
Hs Code.:

tert-butyl-((S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl}-but-3-enyloxy)-diphenyl-silane

Synonyms:tert-butyl-((S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl}-but-3-enyloxy)-diphenyl-silane

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Chemical Property of tert-butyl-((S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl}-but-3-enyloxy)-diphenyl-silane

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Technology Process of tert-butyl-((S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl}-but-3-enyloxy)-diphenyl-silane

There total 10 articles about tert-butyl-((S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl}-but-3-enyloxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 849122-84-5
(S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enyl}-pent-4-en-2-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 849122-85-6
tert-butyl-((S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl}-but-3-enyloxy)-diphenyl-silane

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/j.tet.2004.12.039

Reference yield:

: 848760-88-3
(2S,3R)-1-[(1R,5R,6R)-6-dimethoxymethyl-5-isopropyl-2-methyl-cyclohex-2-enyl]3-(4-methoxyphenoxy)-pent-4-en-2-ol

: 849122-85-6
tert-butyl-((S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl}-but-3-enyloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent / DIPEA; TBAI / CH₂Cl₂ / 7 h / 25 °C

2: LiBF₄ / acetonitrile; H₂O / 6 h / 25 °C

3: 408 mg / NaBH₄ / ethanol / 0.33 h / 25 °C

4: 95 percent / TEA / CH₂Cl₂ / 0 - 25 °C

5: 100 percent / 18-crown-6 / acetonitrile / 2.5 h / 80 °C

6: DIBAL-H / hexane; toluene / 1 h / -78 °C

7: 420 mg / tetrahydrofuran; diethyl ether / 48 h / -78 °C

8: 90 percent / imidazole / CH₂Cl₂ / 16 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; lithium tetrafluoroborate; 18-crown-6 ether; TEA; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; water; toluene; acetonitrile; 7: Brown allylation;
DOI:10.1016/j.tet.2004.12.039

Reference yield:

: 849122-81-2
(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enecarbaldehyde

: 849122-85-6
tert-butyl-((S)-1-{(1R,2R,6R)-6-isopropyl-2-[(2S,3R)-2-methoxymethoxy-3-(4-methoxyphenoxy)-pent-4-enyl]-3-methyl-cyclohex-3-enylmethyl}-but-3-enyloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 408 mg / NaBH₄ / ethanol / 0.33 h / 25 °C

2: 95 percent / TEA / CH₂Cl₂ / 0 - 25 °C

3: 100 percent / 18-crown-6 / acetonitrile / 2.5 h / 80 °C

4: DIBAL-H / hexane; toluene / 1 h / -78 °C

5: 420 mg / tetrahydrofuran; diethyl ether / 48 h / -78 °C

6: 90 percent / imidazole / CH₂Cl₂ / 16 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; 18-crown-6 ether; TEA; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane; toluene; acetonitrile; 5: Brown allylation;
DOI:10.1016/j.tet.2004.12.039