4,5-dihydro-3-(E)-benzylidene-2(3H)-furanthione

Base Information

• Chemical Name: 4,5-dihydro-3-(E)-benzylidene-2(3H)-furanthione
• CAS No.: 144303-03-7
• Molecular Formula: C₁₁H₁₀OS
• Molecular Weight: 190.266
• Mol file: 144303-03-7.mol

Synonyms:4,5-dihydro-3-(E)-benzylidene-2(3H)-furanthione

Chemical Property of 4,5-dihydro-3-(E)-benzylidene-2(3H)-furanthione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-dihydro-3-(E)-benzylidene-2(3H)-furanthione

There total 3 articles about 4,5-dihydro-3-(E)-benzylidene-2(3H)-furanthione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(E)-benzylidenedihydro-2(3H)-furanone (6285-99-0,30959-91-2,40011-26-5) → 4,5-dihydro-3-(E)-benzylidene-2(3H)-furanthione (144303-03-7)

Guidance literature:

With Lawessons reagent; In xylene; for 3h; Heating;

DOI:10.1021/jo00051a024

Reference yield: 53.0%

O-4-Phenylbut-3-yn-1-yl S-methyl dithiocarbonate (105688-46-8) → 4,5-dihydro-3-(E)-benzylidene-2(3H)-furanthione (144303-03-7)

Guidance literature:

With triethyl borane; tri-n-butyl-tin hydride; In hexane; toluene; at -78 ℃; for 0.5h;

DOI:10.1246/bcsj.63.2578

Reference yield:

4-phenyl-but-3-yn-1-ol (10229-11-5) → 4,5-dihydro-3-(E)-benzylidene-2(3H)-furanthione (144303-03-7)

Guidance literature:

Multi-step reaction with 2 steps

2: 53 percent / n-Bu₃SnH, Et₃B / toluene; hexane / 0.5 h / -78 °C / further homoallylic or homopropargylic methyl dithiocarbonates

With triethyl borane; tri-n-butyl-tin hydride; In hexane; toluene;

DOI:10.1246/bcsj.63.2578

upstream raw materials:

(E)-benzylidenedihydro-2(3H)-furanone

O-4-Phenylbut-3-yn-1-yl S-methyl dithiocarbonate

4-phenyl-but-3-yn-1-ol

Downstream raw materials:

(E)-benzylidenedihydro-2(3H)-furanone