(R)-tert-butyl 2-(3-allyl-3-(2-allyl-5-((2,4-difluorophenyl)ethynyl)-benzoyl)ureido)-3-(isobutylthio)propanoate

Base Information

Chemical Name:(R)-tert-butyl 2-(3-allyl-3-(2-allyl-5-((2,4-difluorophenyl)ethynyl)-benzoyl)ureido)-3-(isobutylthio)propanoate
CAS No.:1385774-80-0
Molecular Formula:C₃₃H₃₈F₂N₂O₄S
Molecular Weight:596.739
Hs Code.:

Synonyms:(R)-tert-butyl 2-(3-allyl-3-(2-allyl-5-((2,4-difluorophenyl)ethynyl)-benzoyl)ureido)-3-(isobutylthio)propanoate

Suppliers and Price of (R)-tert-butyl 2-(3-allyl-3-(2-allyl-5-((2,4-difluorophenyl)ethynyl)-benzoyl)ureido)-3-(isobutylthio)propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (R)-tert-butyl 2-(3-allyl-3-(2-allyl-5-((2,4-difluorophenyl)ethynyl)-benzoyl)ureido)-3-(isobutylthio)propanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-tert-butyl 2-(3-allyl-3-(2-allyl-5-((2,4-difluorophenyl)ethynyl)-benzoyl)ureido)-3-(isobutylthio)propanoate

There total 11 articles about (R)-tert-butyl 2-(3-allyl-3-(2-allyl-5-((2,4-difluorophenyl)ethynyl)-benzoyl)ureido)-3-(isobutylthio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1385774-96-8
C₁₁H₂₃NO₂S*ClH

: C₂₂H₁₆ClF₂NO₂

: 1385774-80-0
(R)-tert-butyl 2-(3-allyl-3-(2-allyl-5-((2,4-difluorophenyl)ethynyl)-benzoyl)ureido)-3-(isobutylthio)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 20 ℃; for 0.25h; Inert atmosphere;
DOI:10.1039/c2ob25618e

Reference yield:

: 873330-41-7
(R)-N-(tert-butyloxycarbonyl)-S-(isobutyl)cysteine

: 1385774-80-0
(R)-tert-butyl 2-(3-allyl-3-(2-allyl-5-((2,4-difluorophenyl)ethynyl)-benzoyl)ureido)-3-(isobutylthio)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; di-tert-butyl dicarbonate / 16 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 0.5 h / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; dmap; di-tert-butyl dicarbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; acetonitrile;
DOI:10.1039/c2ob25618e

Reference yield:

: 1385774-73-1
ethyl 5-(2-(2,4-difluorophenyl)ethynyl)-2-hydroxybenzoate

: 1385774-80-0
(R)-tert-butyl 2-(3-allyl-3-(2-allyl-5-((2,4-difluorophenyl)ethynyl)-benzoyl)ureido)-3-(isobutylthio)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: dmap / dichloromethane / 1 h / -78 - 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

3: methanol; sodium hydroxide / dichloromethane / 3 h

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C / Inert atmosphere

5: triethylamine / diethyl ether / 1 h / 20 °C / Inert atmosphere

6: diethyl ether; toluene / 1 h / 0 - 20 °C / Inert atmosphere

7: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.25 h / 0 - 20 °C / Inert atmosphere

With methanol; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile; 2: Stille coupling;
DOI:10.1039/c2ob25618e