3-(4-[[(tert-butoxycarbonyl)(3-phenylpropyl)amino]methyl]phenyl)-(2E)-2-propenoic acid

Base Information

• Chemical Name: 3-(4-[[(tert-butoxycarbonyl)(3-phenylpropyl)amino]methyl]phenyl)-(2E)-2-propenoic acid
• CAS No.: 619324-68-4
• Molecular Formula: C₂₄H₂₉NO₄
• Molecular Weight: 395.499

Synonyms:3-(4-[[(tert-butoxycarbonyl)(3-phenylpropyl)amino]methyl]phenyl)-(2E)-2-propenoic acid

Chemical Property of 3-(4-[[(tert-butoxycarbonyl)(3-phenylpropyl)amino]methyl]phenyl)-(2E)-2-propenoic acid

Chemical Property:

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Technology Process of 3-(4-[[(tert-butoxycarbonyl)(3-phenylpropyl)amino]methyl]phenyl)-(2E)-2-propenoic acid

There total 3 articles about 3-(4-[[(tert-butoxycarbonyl)(3-phenylpropyl)amino]methyl]phenyl)-(2E)-2-propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Phenylpropan-1-amine (2038-57-5) → 3-(4-[[(tert-butoxycarbonyl)(3-phenylpropyl)amino]methyl]phenyl)-(2E)-2-propenoic acid (619324-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₃CN; AcOH / methanol

2: 11.6 g / Et₃N / H₂O; dioxane / 2 h

With sodium cyanoborohydride; acetic acid; triethylamine; In 1,4-dioxane; methanol; water;

DOI:10.1021/jm030235w

Reference yield:

(E)-p-formylcinnamic acid (66885-68-5) → 3-(4-[[(tert-butoxycarbonyl)(3-phenylpropyl)amino]methyl]phenyl)-(2E)-2-propenoic acid (619324-68-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₃CN; AcOH / methanol

2: 11.6 g / Et₃N / H₂O; dioxane / 2 h

With sodium cyanoborohydride; acetic acid; triethylamine; In 1,4-dioxane; methanol; water;

DOI:10.1021/jm030235w

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 3-[4-[[[3-phenylpropyl]amino]methyl]phenyl]-(2E)-2-propenoic acid (619324-67-3) → 3-(4-[[(tert-butoxycarbonyl)(3-phenylpropyl)amino]methyl]phenyl)-(2E)-2-propenoic acid (619324-68-4)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; for 2h;

DOI:10.1021/jm030235w

upstream raw materials:

di-tert-butyl dicarbonate

3-[4-[[[3-phenylpropyl]amino]methyl]phenyl]-(2E)-2-propenoic acid

3-Phenylpropan-1-amine

(E)-p-formylcinnamic acid

Downstream raw materials:

(3-phenylpropyl)-[4-((E)-2-trityloxy-carbamoylvinyl)benzyl]carbamic acid tert-butyl ester

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