tert-butyl (6R)-6-ethyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl (6R)-6-ethyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate
CAS No.:904929-80-2
Molecular Formula:C₂₅H₃₇N₃O₄
Molecular Weight:443.586
Hs Code.:

Synonyms:tert-butyl (6R)-6-ethyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate

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Chemical Property of tert-butyl (6R)-6-ethyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate

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Technology Process of tert-butyl (6R)-6-ethyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate

There total 5 articles about tert-butyl (6R)-6-ethyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 904929-78-8
(2R)-2-ethyl-5-iodo-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-2,3-dihydropyridin-4(1H)-one

: 4248-19-5
tert-butyl carbazate

: 904929-80-2
tert-butyl (6R)-6-ethyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate

Guidance literature:: With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In toluene; at 90 ℃; for 36h;
DOI:10.1021/ol0609006

Reference yield:

: 904929-88-0
(2R)-2-ethyl-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-2,3-dihydropyridin-4(1H)-one

: 904929-80-2
tert-butyl (6R)-6-ethyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / ICl; Cs₂CO₃ / CH₂Cl₂ / 3 h / 0 °C

2: 94 percent / Cs₂CO₃; CuI; N,N-dimethylethylenediamine / toluene / 36 h / 90 °C

With copper(l) iodide; Iodine monochloride; caesium carbonate; N,N`-dimethylethylenediamine; In dichloromethane; toluene;
DOI:10.1021/ol0609006

Reference yield:

: Trifluoro-methanesulfonate4-methoxy-1-{[(E)-(S)-1-methoxymethyl-2-methyl-propylimino]-phenyl-methyl}-pyridinium;

: 904929-80-2
tert-butyl (6R)-6-ethyl-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-4-oxo-1,4,5,6-tetrahydropyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / CH₂Cl₂; diethyl ether / -20 °C

2: 92 percent / ICl; Cs₂CO₃ / CH₂Cl₂ / 3 h / 0 °C

3: 94 percent / Cs₂CO₃; CuI; N,N-dimethylethylenediamine / toluene / 36 h / 90 °C

With copper(l) iodide; Iodine monochloride; caesium carbonate; N,N`-dimethylethylenediamine; In diethyl ether; dichloromethane; toluene;
DOI:10.1021/ol0609006