(3R)-1-azabicyclo[2.2.2]oct-3-yl (4-{3-[6-({[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl}biphenyl-2-yl)carbamate

Base Information

Chemical Name:(3R)-1-azabicyclo[2.2.2]oct-3-yl (4-{3-[6-({[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl}biphenyl-2-yl)carbamate
CAS No.:1616455-82-3
Molecular Formula:C₄₈H₅₇N₅O₇Si
Molecular Weight:844.095
Hs Code.:

(3R)-1-azabicyclo[2.2.2]oct-3-yl (4-{3-[6-({[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl}biphenyl-2-yl)carbamate

Synonyms:(3R)-1-azabicyclo[2.2.2]oct-3-yl (4-{3-[6-({[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl}biphenyl-2-yl)carbamate

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Chemical Property of (3R)-1-azabicyclo[2.2.2]oct-3-yl (4-{3-[6-({[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl}biphenyl-2-yl)carbamate

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Technology Process of (3R)-1-azabicyclo[2.2.2]oct-3-yl (4-{3-[6-({[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl}biphenyl-2-yl)carbamate

There total 12 articles about (3R)-1-azabicyclo[2.2.2]oct-3-yl (4-{3-[6-({[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl}biphenyl-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1616455-81-2
(3R)-1-azabicyclo[2.2.2]oct-3-yl(4-{(1E)-3-[6-({[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]prop-1-en-1-yl}biphenyl-2-yl)carbamate

: 1616455-82-3
(3R)-1-azabicyclo[2.2.2]oct-3-yl (4-{3-[6-({[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl}biphenyl-2-yl)carbamate

Guidance literature:: With ammonium formate; palladium(II) hydroxide; In methanol; at 80 ℃; for 2h;

Reference yield:

: 1616455-78-7
3-allyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-carbaldehyde

: 1616455-82-3
(3R)-1-azabicyclo[2.2.2]oct-3-yl (4-{3-[6-({[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl}biphenyl-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(o-tolyl)phosphine; N-ethyl-N,N-diisopropylamine; palladium diacetate / acetonitrile / 6 h / 90 °C / Sealed tube; Inert atmosphere

2: methanol; N-ethyl-N,N-diisopropylamine; sodium tris(acetoxy)borohydride / 20 °C

3: ammonium formate; palladium(II) hydroxide / methanol / 2 h / 80 °C

With methanol; ammonium formate; palladium diacetate; palladium(II) hydroxide; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In methanol; acetonitrile; 1: |Heck Reaction;

Reference yield:

: 1616455-77-6
3-allyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-carbonitrile

: 1616455-82-3
(3R)-1-azabicyclo[2.2.2]oct-3-yl (4-{3-[6-({[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl}biphenyl-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: formic acid / 75 °C

2: tris-(o-tolyl)phosphine; N-ethyl-N,N-diisopropylamine; palladium diacetate / acetonitrile / 6 h / 90 °C / Sealed tube; Inert atmosphere

3: methanol; N-ethyl-N,N-diisopropylamine; sodium tris(acetoxy)borohydride / 20 °C

4: ammonium formate; palladium(II) hydroxide / methanol / 2 h / 80 °C

With methanol; formic acid; ammonium formate; palladium diacetate; palladium(II) hydroxide; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In methanol; acetonitrile; 2: |Heck Reaction;