(R)-2-benzyloxycarbonylamino-3-chloro-2-methylpropionic acid methyl ester

Base Information

• Chemical Name: (R)-2-benzyloxycarbonylamino-3-chloro-2-methylpropionic acid methyl ester
• CAS No.: 519020-71-4
• Molecular Formula: C₁₃H₁₆ClNO₄
• Molecular Weight: 285.727
• Mol file: 519020-71-4.mol

Synonyms:(R)-2-benzyloxycarbonylamino-3-chloro-2-methylpropionic acid methyl ester

Chemical Property of (R)-2-benzyloxycarbonylamino-3-chloro-2-methylpropionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-benzyloxycarbonylamino-3-chloro-2-methylpropionic acid methyl ester

There total 2 articles about (R)-2-benzyloxycarbonylamino-3-chloro-2-methylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(R)-4-chloromethyl-4-methyl-5-oxo-2-phenyloxazolidine-3-carboxylic acid benzyl ester (519020-70-3) → (R)-2-benzyloxycarbonylamino-3-chloro-2-methylpropionic acid methyl ester (519020-71-4)

Guidance literature:

With methanol; sodium methylate; In tetrahydrofuran; at 0 ℃; for 0.333333h;

Reference yield:

(2R,4R)-3-<(Benzyloxy)carbonyl>-4-methyl-2-phenyl-1,3-oxazolidin-5-one (135923-86-3,135923-87-4,143564-89-0) → (R)-2-benzyloxycarbonylamino-3-chloro-2-methylpropionic acid methyl ester (519020-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / DMPU; LHMDS / tetrahydrofuran / 1.5 h / -78 °C

2: 85 percent / NaOMe; MeOH / tetrahydrofuran / 0.33 h / 0 °C

With methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium methylate; lithium hexamethyldisilazane; In tetrahydrofuran;

upstream raw materials:

(R)-4-chloromethyl-4-methyl-5-oxo-2-phenyloxazolidine-3-carboxylic acid benzyl ester

(2R,4R)-3-<(Benzyloxy)carbonyl>-4-methyl-2-phenyl-1,3-oxazolidin-5-one