(4S-cis)-5-[2'-(formyl)phenyl]-2,2-dimethyl-1,3-dioxolane-4-methanol acetate

Base Information

Chemical Name:(4S-cis)-5-[2'-(formyl)phenyl]-2,2-dimethyl-1,3-dioxolane-4-methanol acetate
CAS No.:473543-36-1
Molecular Formula:C₁₅H₁₈O₅
Molecular Weight:278.305
Hs Code.:

Synonyms:(4S-cis)-5-[2'-(formyl)phenyl]-2,2-dimethyl-1,3-dioxolane-4-methanol acetate

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Chemical Property of (4S-cis)-5-[2'-(formyl)phenyl]-2,2-dimethyl-1,3-dioxolane-4-methanol acetate

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Technology Process of (4S-cis)-5-[2'-(formyl)phenyl]-2,2-dimethyl-1,3-dioxolane-4-methanol acetate

There total 3 articles about (4S-cis)-5-[2'-(formyl)phenyl]-2,2-dimethyl-1,3-dioxolane-4-methanol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 108-24-7
acetic anhydride

: 473543-35-0
(4S-cis)-5-[2'-(formyl)phenyl]-2,2-dimethyl-1,3-dioxolane-4-methanol

: 473543-36-1
(4S-cis)-5-[2'-(formyl)phenyl]-2,2-dimethyl-1,3-dioxolane-4-methanol acetate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 18 ℃; for 17h;
DOI:10.1071/CH02242

Reference yield:

: 160707-67-5
(4S-cis)-5-[2'-(hydroxymethyl)phenyl]-2,2-dimethyl-1,3-dioxolane-4-methanol

: 473543-36-1
(4S-cis)-5-[2'-(formyl)phenyl]-2,2-dimethyl-1,3-dioxolane-4-methanol acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / 'precipitated active' manganese dioxide / 1,2-dimethoxy-ethane / 16 h / 18 °C

2: 55 percent / pyridine; DMAP / CH₂Cl₂ / 17 h / 18 °C

With pyridine; dmap; manganese(IV) oxide; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1071/CH02242

Reference yield:

: 622785-65-3
(4R-cis)-5-(2'-formylphenyl)-2,2-dimethyl-1,3-dioxolane-4-carboxaldehyde

: 473543-36-1
(4S-cis)-5-[2'-(formyl)phenyl]-2,2-dimethyl-1,3-dioxolane-4-methanol acetate

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / methanol / 2 h / 0 °C

2: 73 percent / MnO₂ / 1,2-dimethoxy-ethane / 3 h / 18 °C

3: DMAP; pyridine / CH₂Cl₂ / 2 h / 18 °C

With pyridine; dmap; manganese(IV) oxide; sodium tetrahydroborate; In methanol; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1039/b205230j