N₂-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(ethylamino)ethyl]glycinamide

Base Information

• Chemical Name: N₂-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(ethylamino)ethyl]glycinamide
• CAS No.: 1190889-68-9
• Molecular Formula: C₂₇H₃₄FN₇O₃
• Molecular Weight: 523.61

Synonyms:N₂-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(ethylamino)ethyl]glycinamide

Chemical Property of N₂-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(ethylamino)ethyl]glycinamide

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Technology Process of N₂-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(ethylamino)ethyl]glycinamide

There total 2 articles about N₂-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(ethylamino)ethyl]glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N2-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N2-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N1-{2-[(tert-butoxycarbonyl)(ethyl)amino]ethyl}glycinamide (1190893-66-3) → N2-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N2-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N1-[2-(ethylamino)ethyl]glycinamide (1190889-68-9)

Guidance literature:

N₂-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-{2-[(tert-butoxycarbonyl)(ethyl)amino]ethyl}glycinamide; With trifluoroacetic acid; In dichloromethane; at 0 - 30 ℃; for 1.5h;

With ammonia; In dichloromethane; water;

Reference yield:

→ N2-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N2-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N1-[2-(ethylamino)ethyl]glycinamide (1190889-68-9)

Guidance literature:

Reference yield:

N2-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N2-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N1-[2-(ethylamino)ethyl]glycinamide (1190889-68-9) → N2-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N2-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N1-[2-(ethylamino)ethyl]glycinamide hydrochloride (1190884-33-3)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 - 30 ℃;

upstream raw materials:

N₂-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-{2-[(tert-butoxycarbonyl)(ethyl)amino]ethyl}glycinamide

Downstream raw materials:

N₂-{2-[(5-fluoro-1,3-dihydro-2H-isoindol-2-yl)(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(ethylamino)ethyl]glycinamide hydrochloride

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