(6R)-trans-7-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<<<4-<1-cyclopropyl-6-fluoro-1,4-dihydro-3-<<(4-nitrophenyl)methoxy>carbonyl>-4-oxo-7-quinolinyl>-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphe

Base Information

Chemical Name:(6R)-trans-7-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<<<4-<1-cyclopropyl-6-fluoro-1,4-dihydro-3-<<(4-nitrophenyl)methoxy>carbonyl>-4-oxo-7-quinolinyl>-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphe
CAS No.:127142-84-1
Molecular Formula:C₅₀H₄₇FN₆O₁₂S
Molecular Weight:975.021
Hs Code.:

(6R)-trans-7-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<<<4-<1-cyclopropyl-6-fluoro-1,4-dihydro-3-<<(4-nitrophenyl)methoxy>carbonyl>-4-oxo-7-quinolinyl>-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphe

Synonyms:(6R)-trans-7-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<<<4-<1-cyclopropyl-6-fluoro-1,4-dihydro-3-<<(4-nitrophenyl)methoxy>carbonyl>-4-oxo-7-quinolinyl>-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphe

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Chemical Property of (6R)-trans-7-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<<<4-<1-cyclopropyl-6-fluoro-1,4-dihydro-3-<<(4-nitrophenyl)methoxy>carbonyl>-4-oxo-7-quinolinyl>-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphe

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Technology Process of (6R)-trans-7-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<<<4-<1-cyclopropyl-6-fluoro-1,4-dihydro-3-<<(4-nitrophenyl)methoxy>carbonyl>-4-oxo-7-quinolinyl>-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphe

There total 2 articles about (6R)-trans-7-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<<<4-<1-cyclopropyl-6-fluoro-1,4-dihydro-3-<<(4-nitrophenyl)methoxy>carbonyl>-4-oxo-7-quinolinyl>-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52312-27-3
(6R)-trans-3-(hydroxymethyl)-7-<<(1,1-dimethylethoxy)carbonyl>amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphenyl methyl ester

: 127142-84-1
(6R)-trans-7-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<<<4-<1-cyclopropyl-6-fluoro-1,4-dihydro-3-<<(4-nitrophenyl)methoxy>carbonyl>-4-oxo-7-quinolinyl>-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphe

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylethylamine / toluene; CH₂Cl₂ / 1.67 h / 0 - 20 °C

2: diisopropylethylamine / toluene; CH₂Cl₂ / 3 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1021/jm00113a026

Reference yield:

: 127142-95-4
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid (4-nitrophenyl)methyl ester

: C₂₇H₂₇ClN₂O₇S

: 127142-84-1
(6R)-trans-7-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<<<<4-<1-cyclopropyl-6-fluoro-1,4-dihydro-3-<<(4-nitrophenyl)methoxy>carbonyl>-4-oxo-7-quinolinyl>-1-piperazinyl>carbonyl>oxy>methyl>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid diphe

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; for 3h; Yield given; Ambient temperature;
DOI:10.1021/jm00113a026