17-(cyclopropylmethyl)-4,5a:6β,14-diepoxy-3-benzyloxymorphinan

Base Information

Chemical Name:17-(cyclopropylmethyl)-4,5a:6β,14-diepoxy-3-benzyloxymorphinan
CAS No.:1413433-56-3
Molecular Formula:C₂₇H₂₉NO₃
Molecular Weight:415.532
Hs Code.:

Synonyms:17-(cyclopropylmethyl)-4,5a:6β,14-diepoxy-3-benzyloxymorphinan

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 17-(cyclopropylmethyl)-4,5a:6β,14-diepoxy-3-benzyloxymorphinan

Chemical Property:

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Technology Process of 17-(cyclopropylmethyl)-4,5a:6β,14-diepoxy-3-benzyloxymorphinan

There total 5 articles about 17-(cyclopropylmethyl)-4,5a:6β,14-diepoxy-3-benzyloxymorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₀F₃NO₆S

: 1413433-56-3
17-(cyclopropylmethyl)-4,5a:6β,14-diepoxy-3-benzyloxymorphinan

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at -10 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.06.056

Reference yield:

: 16590-41-3
Naltrexone

: 1413433-56-3
17-(cyclopropylmethyl)-4,5a:6β,14-diepoxy-3-benzyloxymorphinan

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 7 h / Reflux; Inert atmosphere

2: methanol; sodium tetrahydroborate / ethanol / 17 h / 0 - 20 °C / Inert atmosphere

3: pyridine / dichloromethane / 1.25 h / -35 °C / Inert atmosphere

4: lithium triethylborohydride / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere

With pyridine; methanol; sodium tetrahydroborate; lithium triethylborohydride; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; acetone;
DOI:10.1016/j.bmcl.2012.06.056

Reference yield:

: 153567-11-4
2,2,2-trichloroethyl (4'R,7a'R,12b'S)-9'-(benzyloxy)-1',2',4',6'-tetrahydro-3'H,7a'Hspiro[[1,3]dioxolane-2,7'-[4,12]methanobenzofuro[3,2-e]isoquinoline]-3'-carboxylate

: 1413433-56-3
17-(cyclopropylmethyl)-4,5a:6β,14-diepoxy-3-benzyloxymorphinan

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; sodium tetrahydroborate / ethanol / 17 h / 0 - 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 1.25 h / -35 °C / Inert atmosphere

3: lithium triethylborohydride / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere

With pyridine; methanol; sodium tetrahydroborate; lithium triethylborohydride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.06.056