ethyl 2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylate

Base Information

• Chemical Name: ethyl 2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylate
• CAS No.: 1366234-05-0
• Molecular Formula: C₁₂H₁₁FN₂O₂S
• Molecular Weight: 266.296
• Mol file: 1366234-05-0.mol

Synonyms:ethyl 2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylate

Chemical Property of ethyl 2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylate

There total 1 articles about ethyl 2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

ethyl Bromopyruvate (70-23-5) + N-(2-fluorophenyl)thiourea (656-32-6) → ethyl 2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylate (1366234-05-0)

Guidance literature:

In ethanol; Reflux;

DOI:10.1021/acs.jmedchem.5b00226

Reference yield:

ethyl 2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylate (1366234-05-0) → 2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylic acid (1176721-71-3)

Guidance literature:

ethyl 2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylate; With sodium hydroxide; In ethanol; at 65 ℃;

With hydrogenchloride; In water; Cooling with ice bath;

upstream raw materials:

ethyl Bromopyruvate

N-(2-fluorophenyl)thiourea

Downstream raw materials:

2-[(2-fluorophenyl)amino]-1,3-thiazole-4-carboxylic acid