methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-alaninate

Base Information

Chemical Name:methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-alaninate
CAS No.:733742-55-7
Molecular Formula:C₂₇H₃₇N₃O₆
Molecular Weight:499.607
Hs Code.:

Synonyms:methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-alaninate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-alaninate

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Technology Process of methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-alaninate

There total 6 articles about methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 30293-82-4
(S)-(-)-2 isocyanatopropionic acid methyl ester

: 162536-41-6
(2R,3S)-1-(benzylamino)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol

: 733742-55-7
methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-alaninate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 6.5h;
DOI:10.1021/jacs.9b13405

Reference yield:

: 98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

: 733742-55-7
methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-alaninate

Guidance literature:: Multi-step reaction with 2 steps

1: propan-2-ol

2: 20 °C

In isopropyl alcohol;
DOI:10.1124/mol.106.024299

Reference yield:

: 100-46-9
benzylamine

: 733742-55-7
methyl (benzyl((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-4-phenylbutyl)carbamoyl)-L-alaninate

Guidance literature:: Multi-step reaction with 2 steps

1: isopropyl alcohol / 20 h / Inert atmosphere; Reflux

2: dichloromethane / 6.5 h / 0 - 20 °C

In dichloromethane; isopropyl alcohol;
DOI:10.1021/jacs.9b13405