Furo[3,4-e]-1,3-benzodioxol-8-ol,6,8-dihydro-6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,(6S,8R)-

Base Information

Chemical Name:Furo[3,4-e]-1,3-benzodioxol-8-ol,6,8-dihydro-6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,(6S,8R)-
CAS No.:11014-02-1
Molecular Formula:C₂₀H₁₉NO₆
Molecular Weight:369.374
Hs Code.:
Mol file:11014-02-1.mol

Synonyms:Furo[3,4-e]-1,3-benzodioxol-8-ol,6,8-dihydro-6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-,[6S-[6a(R*),8a]]-; Humosine A (7CI,8CI);1,3-Dioxolo[4,5-g]isoquinoline, furo[3,4-e]-1,3-benzodioxol-8-ol deriv.;(+)-Corytensine; (+)-Humosine A; Corytensine; Epi-a-decumbensine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Furo[3,4-e]-1,3-benzodioxol-8-ol,6,8-dihydro-6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,(6S,8R)-

Chemical Property:

Boiling Point:511.3±50.0 °C(Predicted)
PSA：69.62000
Density:1.478±0.06 g/cm3(Predicted)
LogP:2.37330

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Furo[3,4-e]-1,3-benzodioxol-8-ol,6,8-dihydro-6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,(6S,8R)-

There total 12 articles about Furo[3,4-e]-1,3-benzodioxol-8-ol,6,8-dihydro-6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-,(6S,8R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 56083-00-2
(+/-)-bicuculline

: 6883-44-9,11014-02-1,131614-66-9,131614-67-0,131681-55-5,131681-56-6,119565-26-3,119736-64-0,119736-65-1
(+/-)-Egenine

Guidance literature:: With super hydride; In dichloromethane; at -78 - 20 ℃; diastereoselective reaction;
DOI:10.1016/j.tetlet.2010.01.104

Reference yield:

: 131589-16-7,131681-60-2
(1S)-cis-1,5,6,10b-tetrahydro-1-(1,3-benzodioxol-5-yl)-3H-oxazolo<4,3-a>1,3-dioxolo<4,5-g>isoquinolin-3-one

: 6883-44-9,11014-02-1,131614-66-9,131614-67-0,131681-55-5,131681-56-6,119565-26-3,119736-64-0,119736-65-1
(-)-egenine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / LiAlH₄ / tetrahydrofuran / 20 h / Heating

2: 1.) n-BuLi / 1.) THF, -45 deg C, 2 h, 2.) to room temp.

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran;
DOI:10.1021/jo00004a041

Reference yield:

: 131589-15-6
-(1,3-benzodioxol-5-yl)(5,6,7,8-tetrahydro-1,3-dioxolo<4,5-g>isoquinolin-5-yl)methyl 2,2-dimethylpropanoic acid ester

: 6883-44-9,11014-02-1,131614-66-9,131614-67-0,131681-55-5,131681-56-6,119565-26-3,119736-64-0,119736-65-1
(-)-corytensine

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / LiAlH₄ / tetrahydrofuran / 6 h / Heating

2: 86 percent / CH₂Cl₂; toluene / 0 °C

3: 86 percent / LiAlH₄ / tetrahydrofuran / 20 h / Heating

4: 1.) n-BuLi / 1.) THF, -45 deg C, 2 h, 2.) to room temp.

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jo00004a041