(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)cyclopentanecarboxamide trifluoroacetate salt

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Chemical Name:(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)cyclopentanecarboxamide trifluoroacetate salt
CAS No.:1035040-55-1
Molecular Formula:C₂HF₃O₂*C₂₈H₃₃ClN₄O₂
Molecular Weight:607.073
Hs Code.:

Synonyms:(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)cyclopentanecarboxamide trifluoroacetate salt

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Chemical Property of (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)cyclopentanecarboxamide trifluoroacetate salt

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Technology Process of (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)cyclopentanecarboxamide trifluoroacetate salt

There total 3 articles about (R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)cyclopentanecarboxamide trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1035042-01-3
(R)-2-((1-(2-aminoethyl)pyrrolidin-2-yl)methyl)-4-(4-chlorobenzyl)phthalazin-1(2H)-one

: 3400-45-1
cyclopentanecarboxylic acid

: 76-05-1
trifluoroacetic acid

: 1035040-55-1
(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)cyclopentanecarboxamide trifluoroacetate salt

Guidance literature:: (R)-2-((1-(2-aminoethyl)pyrrolidin-2-yl)methyl)-4-(4-chlorobenzyl)phthalazin-1(2H)-one; cyclopentanecarboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

trifluoroacetic acid;
DOI:10.1021/acsmedchemlett.7b00112

Reference yield:

: 955359-79-2
4-[(4-chlorophenyl)methyl]-2-{[(2R)-2-pyrrolidinyl]methyl}-1(2H)-phthalazinone

: 1035040-55-1
(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)cyclopentanecarboxamide trifluoroacetate salt

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / butanone / 114 h / 20 - 80 °C / Inert atmosphere

2: hydrazine hydrate / ethanol / 1.25 h / 80 °C

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; triethylamine; In ethanol; N,N-dimethyl-formamide; butanone;
DOI:10.1021/acsmedchemlett.7b00112

Reference yield:

: 1035041-98-5
(R)-2-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)isoindoline-1,3-dione

: 1035040-55-1
(R)-N-(2-(2-((4-(4-chlorobenzyl)-1-oxophthalazin-2(1H)-yl)methyl)pyrrolidin-1-yl)ethyl)cyclopentanecarboxamide trifluoroacetate salt

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 1.25 h / 80 °C

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; triethylamine; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.7b00112