(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-N-[(S)-1-(2-cyclohexyl-ethylcarbamoyl)-ethyl]-3-methyl-butyramide

Base Information

Chemical Name:(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-N-[(S)-1-(2-cyclohexyl-ethylcarbamoyl)-ethyl]-3-methyl-butyramide
CAS No.:1026248-05-4
Molecular Formula:C₂₇H₄₂N₄O₅
Molecular Weight:502.654
Hs Code.:

Synonyms:(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-N-[(S)-1-(2-cyclohexyl-ethylcarbamoyl)-ethyl]-3-methyl-butyramide

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Chemical Property of (S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-N-[(S)-1-(2-cyclohexyl-ethylcarbamoyl)-ethyl]-3-methyl-butyramide

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Technology Process of (S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-N-[(S)-1-(2-cyclohexyl-ethylcarbamoyl)-ethyl]-3-methyl-butyramide

There total 3 articles about (S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-N-[(S)-1-(2-cyclohexyl-ethylcarbamoyl)-ethyl]-3-methyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-2-[(S)-2-Acetylamino-3-(4-benzyloxy-phenyl)-propionylamino]-N-[(S)-1-(2-cyclohexyl-ethylcarbamoyl)-ethyl]-3-methyl-butyramide

: 1026248-05-4
(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-N-[(S)-1-(2-cyclohexyl-ethylcarbamoyl)-ethyl]-3-methyl-butyramide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; under 2585.7 - 2844.3 Torr;
DOI:10.1021/jm9802766

Reference yield:

: 73535-46-3
N-ac-(O-benzyl)tyrosine

: 1026248-05-4
(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-N-[(S)-1-(2-cyclohexyl-ethylcarbamoyl)-ethyl]-3-methyl-butyramide

Guidance literature:: Multi-step reaction with 3 steps

2: HATU, HOAt, NMM / tetrahydrofuran / 6 h

3: H₂ / 20percent Pd/C / methanol / 2585.7 - 2844.3 Torr

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; hydrogen; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm9802766

Reference yield:

: 198628-73-8
(S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-benzyloxy-phenyl)-propionylamino]-3-methyl-butyrylamino}-propionic acid

: 1026248-05-4
(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-N-[(S)-1-(2-cyclohexyl-ethylcarbamoyl)-ethyl]-3-methyl-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: HATU, HOAt, NMM / tetrahydrofuran / 6 h

2: H₂ / 20percent Pd/C / methanol / 2585.7 - 2844.3 Torr

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; hydrogen; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm9802766