(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid benzyl ester

Base Information

Chemical Name:(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid benzyl ester
CAS No.:701261-91-8
Molecular Formula:C₂₇H₂₉NO₅
Molecular Weight:447.531
Hs Code.:

Synonyms:(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid benzyl ester

Chemical Property:

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Technology Process of (R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid benzyl ester

There total 4 articles about (R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 47004-38-6
D-phenylalanine benzyl ester

: 282551-84-2
MOM-D-phenyllactic acid

: 701261-91-8
(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/ja030669g

Reference yield:

: 828-01-3,7326-19-4,20312-36-1,156-05-8
D-phenyllactic acid

: 701261-91-8
(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether

2: 0.460 g / i-Pr₂NEt / CH₂Cl₂

3: 100 percent / aq. LiOH / tetrahydrofuran / 1 h

4: 89 percent / EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

With lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ja030669g

Reference yield:

: 27000-00-6
methyl 2-hydroxy-3-phenylpropionate

: 701261-91-8
(R)-2-((R)-2-Methoxymethoxy-3-phenyl-propionylamino)-3-phenyl-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 0.460 g / i-Pr₂NEt / CH₂Cl₂

2: 100 percent / aq. LiOH / tetrahydrofuran / 1 h

3: 89 percent / EDC; HOBt; Et₃N / CH₂Cl₂ / 20 °C

With lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja030669g