C₁₇H₁₈ClNO

Base Information

• Chemical Name: C₁₇H₁₈ClNO
• CAS No.: 1204672-30-9
• Molecular Formula: C₁₇H₁₈ClNO
• Molecular Weight: 287.789
• Mol file: 1204672-30-9.mol

Synonyms:C₁₇H₁₈ClNO

Chemical Property of C₁₇H₁₈ClNO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₈ClNO

There total 5 articles about C₁₇H₁₈ClNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C22H26ClNO3 → C17H18ClNO (1204672-30-9)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 18h;

DOI:10.1016/j.bmcl.2012.12.061

Reference yield:

tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate (199174-24-8) → C17H18ClNO (1204672-30-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / 0.17 h / 0 °C

2: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / Sonication

4: hydrogenchloride / ethanol / 18 h / 20 °C

With hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; sodium hydrogencarbonate; triphenylphosphine; potassium bromide; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2012.12.061

Reference yield:

(S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester (191348-04-6) → C17H18ClNO (1204672-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / -78 - 20 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / Sonication

3: hydrogenchloride / ethanol / 18 h / 20 °C

With hydrogenchloride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2012.12.061

upstream raw materials:

tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

(S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester

1,1-dimethylethyl (3S)-3-[(S)-hydroxyphenylmethyl]-1-pyrrolidinecarboxylate

Refernces

• 1、 -. "3-(PHENOXYPHENYLMETHYL)PYRROLIDINE COMPOUNDS". Page/Page column 46-47. . Retrieved 2010/02/17.