2-(4-(3-bromo-4-fluoro-phenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)-6-methylpyridine

Base Information

Chemical Name:2-(4-(3-bromo-4-fluoro-phenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)-6-methylpyridine
CAS No.:879487-26-0
Molecular Formula:C₂₁H₂₅BrFN₃OSi
Molecular Weight:462.437
Hs Code.:

Synonyms:2-(4-(3-bromo-4-fluoro-phenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)-6-methylpyridine

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Chemical Property of 2-(4-(3-bromo-4-fluoro-phenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)-6-methylpyridine

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Technology Process of 2-(4-(3-bromo-4-fluoro-phenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)-6-methylpyridine

There total 2 articles about 2-(4-(3-bromo-4-fluoro-phenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 879487-25-9
2-[4-(3-bromo-4-fluorophenyl)-1H-imidazol-5-yl]-6-methylpyridine

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 879487-26-0
2-(4-(3-bromo-4-fluoro-phenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)-6-methylpyridine

: 879487-27-1
2-(5-(3-bromo-4-fluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-4-yl)-6-methylpyridine

Guidance literature:: 2-[4-(3-bromo-4-fluorophenyl)-1H-imidazol-5-yl]-6-methylpyridine; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.25h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 879486-35-8
1-(3-bromo-4-fluorophenyl)-2-(6-methylpyridin-2-yl)ethanone

: 879487-26-0
2-(4-(3-bromo-4-fluoro-phenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)-6-methylpyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen bromide / water; dimethyl sulfoxide / 3 h / 60 °C

1.2: 1.5 h / Heating / reflux

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

2.2: 2 h / 20 °C

With hydrogen bromide; sodium hydride; In tetrahydrofuran; water; dimethyl sulfoxide;

Reference yield:

: 879487-26-0
2-(4-(3-bromo-4-fluoro-phenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl)-6-methylpyridine

: 879487-27-1
2-(5-(3-bromo-4-fluorophenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-4-yl)-6-methylpyridine

: 761446-44-0
1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: C₂₅H₃₀FN₅OSi

: 879487-28-2
C₂₅H₃₀FN₅OSi

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 4h; Heating / reflux;