1,1-dimethylethyl [(3-bromo-2-hydroxyphenyl)methyl](2-hydroxyethyl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl [(3-bromo-2-hydroxyphenyl)methyl](2-hydroxyethyl)carbamate
CAS No.:1167416-81-0
Molecular Formula:C₁₄H₂₀BrNO₄
Molecular Weight:346.221
Hs Code.:

Synonyms:1,1-dimethylethyl [(3-bromo-2-hydroxyphenyl)methyl](2-hydroxyethyl)carbamate

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Chemical Property of 1,1-dimethylethyl [(3-bromo-2-hydroxyphenyl)methyl](2-hydroxyethyl)carbamate

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Technology Process of 1,1-dimethylethyl [(3-bromo-2-hydroxyphenyl)methyl](2-hydroxyethyl)carbamate

There total 3 articles about 1,1-dimethylethyl [(3-bromo-2-hydroxyphenyl)methyl](2-hydroxyethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1167416-80-9
2-bromo-6-{[(2-hydroxyethyl)amino]methyl}phenol

: 1167416-81-0
1,1-dimethylethyl [(3-bromo-2-hydroxyphenyl)methyl](2-hydroxyethyl)carbamate

Guidance literature:: With triethylamine; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 74.5h; Cooling with ice;
DOI:10.1021/jm200609t

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 1167416-81-0
1,1-dimethylethyl [(3-bromo-2-hydroxyphenyl)methyl](2-hydroxyethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; magnesium chloride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

1.2: 6 h / Reflux; Inert atmosphere

2.1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

3.1: triethylamine / tetrahydrofuran; methanol / 74.5 h / 0 - 20 °C / Cooling with ice

With sodium tris(acetoxy)borohydride; triethylamine; magnesium chloride; In tetrahydrofuran; methanol;
DOI:10.1021/jm200609t

Reference yield:

: 1829-34-1
2-hydroxy-3-bromobenzaldehyde

: 1167416-81-0
1,1-dimethylethyl [(3-bromo-2-hydroxyphenyl)methyl](2-hydroxyethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran; methanol / 74.5 h / 0 - 20 °C / Cooling with ice

With sodium tris(acetoxy)borohydride; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/jm200609t