(4R,5S,2'R,3'S)-3-(3'-azido-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone

Base Information

Chemical Name:(4R,5S,2'R,3'S)-3-(3'-azido-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone
CAS No.:410087-07-9
Molecular Formula:C₁₇H₂₂N₄O₃
Molecular Weight:330.387
Hs Code.:

Synonyms:(4R,5S,2'R,3'S)-3-(3'-azido-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4R,5S,2'R,3'S)-3-(3'-azido-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone

Chemical Property:

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Technology Process of (4R,5S,2'R,3'S)-3-(3'-azido-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone

There total 4 articles about (4R,5S,2'R,3'S)-3-(3'-azido-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 410087-05-7
(4R,5S,2'R,3'R)-3-(3'-bromo-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone

: 410087-07-9
(4R,5S,2'R,3'S)-3-(3'-azido-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone

Guidance literature:: With sodium azide; 15-crown-5; In N,N-dimethyl-formamide; at 70 ℃;
DOI:10.1021/jo010176z

Reference yield:

: 77877-20-4
(4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one

: 410087-07-9
(4R,5S,2'R,3'S)-3-(3'-azido-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1.1: dibutylboron triflate; diisopropylethylamine / CH₂Cl₂ / 0 °C

1.2: 86 percent / CH₂Cl₂ / -78 - 20 °C

2.1: 68 percent / pyridine / 20 °C

3.1: 70 percent / lithium bromide / acetone / Heating

4.1: sodium azide; 15-crown-5 / dimethylformamide / 70 °C

With pyridine; sodium azide; 15-crown-5; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; lithium bromide; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo010176z

Reference yield:

: 260395-13-9
(4R,5S,2'R,3'S)-3-(3'-hydroxy-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone

: 410087-07-9
(4R,5S,2'R,3'S)-3-(3'-azido-2'-methylhexanoyl)-5-phenyl-4-methyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / pyridine / 20 °C

2: 70 percent / lithium bromide / acetone / Heating

3: sodium azide; 15-crown-5 / dimethylformamide / 70 °C

With pyridine; sodium azide; 15-crown-5; lithium bromide; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo010176z