2-benzyloxycarbonylamino-6-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-hexanoic acid

Base Information

Chemical Name:2-benzyloxycarbonylamino-6-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-hexanoic acid
CAS No.:913338-34-8
Molecular Formula:C₃₆H₅₂N₂O₆
Molecular Weight:608.819
Hs Code.:

2-benzyloxycarbonylamino-6-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1<i>H</i>-cyclopenta[<i>a</i>]phenanthren-17-yl)-propionylamino]-hexanoic acid

Synonyms:2-benzyloxycarbonylamino-6-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-hexanoic acid

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Chemical Property of 2-benzyloxycarbonylamino-6-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-hexanoic acid

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Technology Process of 2-benzyloxycarbonylamino-6-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-hexanoic acid

There total 3 articles about 2-benzyloxycarbonylamino-6-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 913338-76-8
6-[2-(3-acetoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-2-benzyloxycarbonylamino-hexanoic acid benzyl ester

: 913338-34-8
2-benzyloxycarbonylamino-6-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-hexanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; at 50 ℃; for 24h;
DOI:10.1021/jm060290f

Reference yield:

: 5591-94-6
N^(α)-benzyloxycarbonyl-L-lysine benzyl ester

: 913338-34-8
2-benzyloxycarbonylamino-6-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: HOBt; TBTU; DIPEA / dimethylformamide / 1 h

1.2: 80 percent / dimethylformamide

2.1: 36 percent / aq. LiOH / tetrahydrofuran / 24 h / 50 °C

With lithium hydroxide; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm060290f

Reference yield:

: 1474-14-2
3β-acetoxybisnor-5-cholenic acid

: 913338-34-8
2-benzyloxycarbonylamino-6-[2-(3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-propionylamino]-hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: HOBt; TBTU; DIPEA / dimethylformamide / 1 h

1.2: 80 percent / dimethylformamide

2.1: 36 percent / aq. LiOH / tetrahydrofuran / 24 h / 50 °C

With lithium hydroxide; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm060290f