benzyl ((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamate

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Chemical Name:benzyl ((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamate
CAS No.:1385183-82-3
Molecular Formula:C₂₅H₃₄N₄O₆
Molecular Weight:486.568
Hs Code.:

Synonyms:benzyl ((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamate

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Chemical Property of benzyl ((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamate

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Technology Process of benzyl ((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamate

There total 12 articles about benzyl ((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1385183-69-6
C₂₅H₃₆N₄O₆

: 1385183-82-3
benzyl ((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jm5019934

Reference yield:

: 1350624-48-4
C₂₂H₃₁N₃O₆

: 1385183-82-3
benzyl ((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium borohydride / tetrahydrofuran

2: Dess-Martin periodane / dichloromethane

3: ethyl acetate

4: methanol; potassium carbonate

5: Dess-Martin periodane / dichloromethane

With methanol; lithium borohydride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; ethyl acetate; 2: Dess-Martin oxidation / 5: Dess-Martin oxidation;
DOI:10.1016/j.bmcl.2012.05.055

Reference yield:

: 1333231-43-8
C₂₁H₃₁N₃O₅

: 1385183-82-3
benzyl ((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: Dess-Martin periodane / dichloromethane

2: ethyl acetate

3: methanol; potassium carbonate

4: Dess-Martin periodane / dichloromethane

With methanol; potassium carbonate; Dess-Martin periodane; In dichloromethane; ethyl acetate; 1: Dess-Martin oxidation / 4: Dess-Martin oxidation;
DOI:10.1016/j.bmcl.2012.05.055