(Z)-2-(3,5-Difluoro-phenyl)-2,9-dimethoxy-6-phenyl-non-5-ene-3,7-diynoic acid

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Chemical Name:(Z)-2-(3,5-Difluoro-phenyl)-2,9-dimethoxy-6-phenyl-non-5-ene-3,7-diynoic acid
CAS No.:259739-98-5
Molecular Formula:C₂₃H₁₈F₂O₄
Molecular Weight:396.39
Hs Code.:

Synonyms:(Z)-2-(3,5-Difluoro-phenyl)-2,9-dimethoxy-6-phenyl-non-5-ene-3,7-diynoic acid

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Chemical Property of (Z)-2-(3,5-Difluoro-phenyl)-2,9-dimethoxy-6-phenyl-non-5-ene-3,7-diynoic acid

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Technology Process of (Z)-2-(3,5-Difluoro-phenyl)-2,9-dimethoxy-6-phenyl-non-5-ene-3,7-diynoic acid

There total 6 articles about (Z)-2-(3,5-Difluoro-phenyl)-2,9-dimethoxy-6-phenyl-non-5-ene-3,7-diynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 259739-91-8
2-phenylsulphonylethyl 3,5-difluorobenzoylformate

: 259739-98-5
(Z)-2-(3,5-Difluoro-phenyl)-2,9-dimethoxy-6-phenyl-non-5-ene-3,7-diynoic acid

Guidance literature:: With amberlyst-15; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; at 0 ℃; for 0.166667h;
DOI:10.1016/S0040-4039(99)02009-2

Reference yield:

: 32904-86-2
4-methoxy-1-phenylbut-2-yn-1-one

: 259739-98-5
(Z)-2-(3,5-Difluoro-phenyl)-2,9-dimethoxy-6-phenyl-non-5-ene-3,7-diynoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: Zn / tetrahydrofuran / 0.08 h / 0 °C

2: MsCl; Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

3: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

4: Ag₂O; CaSO₄ / 9 h / 20 °C

5: mCPBA / CH₂Cl₂ / 0.17 h / 20 °C

6: 80 percent / DBU; Amberlyst-15 / methanol / 0.17 h / 0 °C

With calcium sulfate; n-butyllithium; amberlyst-15; methanesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; zinc; In tetrahydrofuran; methanol; dichloromethane; 1: alkynylation / 2: Dehydration / 3: Addition / 4: Methylation / 5: Oxidation / 6: Hydrolysis;
DOI:10.1016/S0040-4039(99)02009-2

Reference yield:

: 259739-90-7
[(Z)-1-(3-Methoxy-prop-1-ynyl)-but-1-en-3-ynyl]-benzene

: 259739-98-5
(Z)-2-(3,5-Difluoro-phenyl)-2,9-dimethoxy-6-phenyl-non-5-ene-3,7-diynoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

2: Ag₂O; CaSO₄ / 9 h / 20 °C

3: mCPBA / CH₂Cl₂ / 0.17 h / 20 °C

4: 80 percent / DBU; Amberlyst-15 / methanol / 0.17 h / 0 °C

With calcium sulfate; n-butyllithium; amberlyst-15; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; 1: Addition / 2: Methylation / 3: Oxidation / 4: Hydrolysis;
DOI:10.1016/S0040-4039(99)02009-2