ethyl 6-(phenyl)ethynyl-1-(pyridin-4-yl)methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

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Chemical Name:ethyl 6-(phenyl)ethynyl-1-(pyridin-4-yl)methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
CAS No.:1227077-06-6
Molecular Formula:C₂₃H₁₈N₄O₂
Molecular Weight:382.422
Hs Code.:

Synonyms:ethyl 6-(phenyl)ethynyl-1-(pyridin-4-yl)methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

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Chemical Property of ethyl 6-(phenyl)ethynyl-1-(pyridin-4-yl)methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

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Technology Process of ethyl 6-(phenyl)ethynyl-1-(pyridin-4-yl)methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

There total 1 articles about ethyl 6-(phenyl)ethynyl-1-(pyridin-4-yl)methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1227077-01-1
ethyl 6-oxo-1-(pyridin-4-ylmethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

: 536-74-3
phenylacetylene

: 1227077-06-6
ethyl 6-(phenyl)ethynyl-1-(pyridin-4-yl)methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

Guidance literature:: ethyl 6-oxo-1-(pyridin-4-ylmethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-4-carboxylate; With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; at 25 ℃; for 2h; Inert atmosphere;

phenylacetylene; With dichloro bis(acetonitrile) palladium(II); caesium carbonate; CyJohnPhos; In 1,4-dioxane; at 25 - 85 ℃; Inert atmosphere;
DOI:10.1021/ol100657n

Reference yield: 65.0%

: 1227077-06-6
ethyl 6-(phenyl)ethynyl-1-(pyridin-4-yl)methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

: 1426935-41-2
C₂₁H₁₄N₄O₂

Guidance literature:: ethyl 6-(phenyl)ethynyl-1-(pyridin-4-yl)methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 4h;

With hydrogenchloride; In water;
DOI:10.1021/jm301709s