(S)-2-Acetoxy-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-2',4',6'-trimethyl-biphenyl-4-yl ester

Base Information

Chemical Name:(S)-2-Acetoxy-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-2',4',6'-trimethyl-biphenyl-4-yl ester
CAS No.:854937-86-3
Molecular Formula:C₃₂H₃₀IO₅P
Molecular Weight:652.465
Hs Code.:

Synonyms:(S)-2-Acetoxy-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-2',4',6'-trimethyl-biphenyl-4-yl ester

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Chemical Property of (S)-2-Acetoxy-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-2',4',6'-trimethyl-biphenyl-4-yl ester

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Technology Process of (S)-2-Acetoxy-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-2',4',6'-trimethyl-biphenyl-4-yl ester

There total 8 articles about (S)-2-Acetoxy-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-2',4',6'-trimethyl-biphenyl-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 885722-48-5
3-(diphenylphosphinoyl)-2-iodo-4-mesityl-phenol

: 36394-75-9
(S)-2-acetoxypropanoyl chloride

: 854937-86-3
(S)-2-Acetoxy-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-2',4',6'-trimethyl-biphenyl-4-yl ester

Guidance literature:: With TEA; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2005.03.183

Reference yield:

: 854937-83-0
2'-bromo-4'-methoxy-2,4,6-trimethyl-biphenyl

: 854937-86-3
(S)-2-Acetoxy-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-2',4',6'-trimethyl-biphenyl-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran / 3 h / -78 °C

1.2: tetrahydrofuran / 12 h / -78 - 20 °C

2.1: H₂O₂ / methanol / 1 h / 20 °C

3.1: LDA / tetrahydrofuran / 1.5 h / -78 °C

3.2: 78 percent / I₂ / tetrahydrofuran / 2 h / -78 - 20 °C

4.1: 93 percent / BBr₃ / CH₂Cl₂ / 20 h / 20 °C

5.1: 72 percent / TEA / CH₂Cl₂ / 1 h / 20 °C

With n-butyllithium; TEA; dihydrogen peroxide; boron tribromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tetlet.2005.03.183

Reference yield:

: (4-methoxy-2',4',6'-trimethyl-biphenyl-2-yl)-diphenyl-phosphane

: 854937-86-3
(S)-2-Acetoxy-propionic acid 2-(diphenyl-phosphinoyl)-3-iodo-2',4',6'-trimethyl-biphenyl-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂O₂ / methanol / 1 h / 20 °C

2.1: LDA / tetrahydrofuran / 1.5 h / -78 °C

2.2: 78 percent / I₂ / tetrahydrofuran / 2 h / -78 - 20 °C

3.1: 93 percent / BBr₃ / CH₂Cl₂ / 20 h / 20 °C

4.1: 72 percent / TEA / CH₂Cl₂ / 1 h / 20 °C

With TEA; dihydrogen peroxide; boron tribromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tetlet.2005.03.183