(R)-2-((1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N,N-dimethylacetamide

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Chemical Name:(R)-2-((1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N,N-dimethylacetamide
CAS No.:1374239-11-8
Molecular Formula:C₂₃H₂₇Cl₂N₇O₂
Molecular Weight:504.419
Hs Code.:

Synonyms:(R)-2-((1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N,N-dimethylacetamide

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Chemical Property of (R)-2-((1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N,N-dimethylacetamide

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Technology Process of (R)-2-((1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N,N-dimethylacetamide

There total 12 articles about (R)-2-((1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1374242-16-6
(R)-2-((1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N,N-dimethylacetamide

: 1374239-11-8
(R)-2-((1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N,N-dimethylacetamide

Guidance literature:: With methanol; potassium carbonate; at 70 ℃; for 2h;

Reference yield:

: 479633-63-1
4-chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine

: 1374239-11-8
(R)-2-((1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: hydrogenchloride; water / methanol / 0 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

5.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 0 °C

5.2: 0 - 20 °C

6.1: sodium periodate / dichloromethane / 0 - 20 °C

7.1: sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide / acetonitrile; water / 0 - 20 °C

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 - 20 °C

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 760.05 Torr

10.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

11.1: potassium carbonate; methanol / 2 h / 70 °C

With hydrogenchloride; methanol; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; water; hydrogen; dihydrogen peroxide; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 188111-79-7
tert-butyl (3R)3-aminopiperidine-1-carboxylate

: 1374239-11-8
(R)-2-((1-(2-(3,5-dichlorophenylamino)acetyl)piperidin-3-yl)(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 15 h / 20 °C

2.1: hydrogenchloride; water / methanol / 0 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

5.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 0 °C

5.2: 0 - 20 °C

6.1: sodium periodate / dichloromethane / 0 - 20 °C

7.1: sodium chlorite; sodium dihydrogenphosphate; dihydrogen peroxide / acetonitrile; water / 0 - 20 °C

8.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0 - 20 °C

9.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 760.05 Torr

10.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0 - 20 °C

11.1: potassium carbonate; methanol / 2 h / 70 °C

With hydrogenchloride; methanol; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; water; hydrogen; dihydrogen peroxide; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;