tert-Butyl (2S,4S)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylprolinate

Base Information

Chemical Name:tert-Butyl (2S,4S)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylprolinate
CAS No.:179863-67-3
Molecular Formula:C₃₁H₄₅NO₅Si
Molecular Weight:539.788
Hs Code.:

Synonyms:tert-Butyl (2S,4S)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylprolinate

Suppliers and Price of tert-Butyl (2S,4S)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylprolinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-Butyl (2S,4S)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylprolinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-Butyl (2S,4S)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylprolinate

There total 3 articles about tert-Butyl (2S,4S)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylprolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 163190-47-4
(2S,4S)-N-tert-butoxycarbonyl-2-tert-butoxycarbonyl-4-hydroxymethylpyrrolidine

: 179863-67-3
tert-Butyl (2S,4S)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylprolinate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(94)02475-Q

Reference yield:

: 84348-38-9,1427175-11-8
(S)-1-(tert-butoxycarbonyl)-4-methylenepyrrolidine-2-carboxylic acid

: 179863-67-3
tert-Butyl (2S,4S)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylprolinate

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / DMAP, Et₃N / acetonitrile / Ambient temperature

2: 1.) Me₂S*BH₃, 2.) aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, 20 deg C, 24 h, 2.) 20 deg C, 30 min

3: imidazole / dimethylformamide / 48 h / Ambient temperature

With 1H-imidazole; dmap; sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; triethylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/P19960001131

Reference yield:

: 163190-46-3
tert-Butyl (2S)-N-tert-butoxycarbonyl-4-methylideneprolinate

: 179863-67-3
tert-Butyl (2S,4S)-N-tert-butoxycarbonyl-4-tert-butyldiphenylsilyloxymethylprolinate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Me₂S*BH₃, 2.) aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, 20 deg C, 24 h, 2.) 20 deg C, 30 min

2: imidazole / dimethylformamide / 48 h / Ambient temperature

With 1H-imidazole; sodium hydroxide; dimethylsulfide borane complex; dihydrogen peroxide; In N,N-dimethyl-formamide;
DOI:10.1039/P19960001131