1R-{(3-[(E)-2-(7-chloroquinolin-2-yl) vinyl] phenyl)}-3-[2-(prop-1-en-2-yl) phenyl] propan-1-ol hydrochloride

Base Information

Chemical Name:1R-{(3-[(E)-2-(7-chloroquinolin-2-yl) vinyl] phenyl)}-3-[2-(prop-1-en-2-yl) phenyl] propan-1-ol hydrochloride
CAS No.:1351973-51-7
Molecular Formula:C₂₉H₂₆ClNO*ClH
Molecular Weight:476.445
Hs Code.:

Synonyms:1R-{(3-[(E)-2-(7-chloroquinolin-2-yl) vinyl] phenyl)}-3-[2-(prop-1-en-2-yl) phenyl] propan-1-ol hydrochloride

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Chemical Property of 1R-{(3-[(E)-2-(7-chloroquinolin-2-yl) vinyl] phenyl)}-3-[2-(prop-1-en-2-yl) phenyl] propan-1-ol hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1R-{(3-[(E)-2-(7-chloroquinolin-2-yl) vinyl] phenyl)}-3-[2-(prop-1-en-2-yl) phenyl] propan-1-ol hydrochloride

There total 6 articles about 1R-{(3-[(E)-2-(7-chloroquinolin-2-yl) vinyl] phenyl)}-3-[2-(prop-1-en-2-yl) phenyl] propan-1-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352029-52-7
1R-{(3-[(E)-2-(7-chloroquinolin-2-yl) vinyl] phenyl)}-3-[2-(prop-1-en-2-yl) phenyl] propan-1-ol

: 1351973-51-7
1R-{(3-[(E)-2-(7-chloroquinolin-2-yl) vinyl] phenyl)}-3-[2-(prop-1-en-2-yl) phenyl] propan-1-ol hydrochloride

Guidance literature:: With hydrogenchloride; In water; at 25 - 30 ℃; pH=6.5 - 7;

Reference yield:

: 1197374-09-6
(S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-isopropenylphenyl)propyl acetate

: 1351973-51-7
1R-{(3-[(E)-2-(7-chloroquinolin-2-yl) vinyl] phenyl)}-3-[2-(prop-1-en-2-yl) phenyl] propan-1-ol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 25 - 30 °C

2: hydrogenchloride / water / 25 - 30 °C / pH 6.5 - 7

With hydrogenchloride; water; sodium hydroxide; In tetrahydrofuran; methanol; water;

Reference yield:

: 149968-11-6
methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate

: 1351973-51-7
1R-{(3-[(E)-2-(7-chloroquinolin-2-yl) vinyl] phenyl)}-3-[2-(prop-1-en-2-yl) phenyl] propan-1-ol hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: (-)-diisopinocamphenylborane chloride / dichloromethane / -5 - 0 °C

2: cerium(III) chloride / tetrahydrofuran / 0 - 5 °C

3: dmap; triethylamine / dichloromethane / 0 - 5 °C

4: toluene-4-sulfonic acid / dichloromethane / 25 - 30 °C

5: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 25 - 30 °C

6: hydrogenchloride / water / 25 - 30 °C / pH 6.5 - 7

With hydrogenchloride; dmap; cerium(III) chloride; water; toluene-4-sulfonic acid; triethylamine; (-)-diisopinocamphenylborane chloride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 2: Grignard reaction;