Norethisterone enanthate

Base Information

• Chemical Name: Norethisterone enanthate
• CAS No.: 3836-23-5
• Molecular Formula: C27H38O3
• Molecular Weight: 410.597
• European Community (EC) Number: 223-326-7
• NSC Number: 22846
• UNII: HY3S2K0J0F
• DSSTox Substance ID: DTXSID2048664
• Nikkaji Number: J59.376A
• Wikipedia: Norethisterone_enanthate
• Wikidata: Q7050956
• Metabolomics Workbench ID: 155038
• ChEMBL ID: CHEMBL3187229
• Mol file: 3836-23-5.mol

Synonyms:(17 alpha)-17-((1-oxoheptyl)oxy)-19-norpregn-4-en-20-yn-3-one;19-norethindrone enanthate;norethindrone enanthate;norethisterone enanthate;norethisterone oenanthate

Chemical Property of Norethisterone enanthate

Chemical Property:

• Vapor Pressure: 9.93E-11mmHg at 25°C
• Melting Point: 69.5°C
• Refractive Index: 1.54
• Boiling Point: 515.3 °C at 760 mmHg
• Flash Point: 219 °C
• PSA: 43.37000
• Density: 1.08 g/cm³
• LogP: 6.01380
• Storage Temp.: Refrigerator, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 8
• Exact Mass: 410.28209507
• Heavy Atom Count: 30
• Complexity: 770

Purity/Quality:

99% ^*data from raw suppliers

Norethisterone Enanthate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCC(=O)OC1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C)C#C
• Isomeric SMILES: CCCCCCC(=O)O[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@H]34)C)C#C
• Recent ClinicalTrials: The Effect of Norethisterone Enanthate on Recurrent Bacterial Vaginosis
• Recent EU Clinical Trials: Sperm Suppression and Contraceptive Protection provived by Norethisterone Enantate (NET-EN) combined with Testosterone Undecanoate (TU) in healthy men.
• Uses: Norethisterone enanthate is a useful compound to study chem.-chem. interaction for predicting biological functions. It also has antigonadotropic effects and can be used as a hormonal contraceptive.
• Therapeutic Function: Progestin

Technology Process of Norethisterone enanthate

There total 3 articles about Norethisterone enanthate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

oenanthic acid (111-14-8) + 17α-ethynyl-19-nortestosterone (68-22-4,1670-34-4,5738-59-0,17554-51-7,19698-69-2,23944-76-5,23944-77-6,24377-25-1,32214-10-1,38673-36-8,99883-39-3,148261-68-1) → Norethisterone oenanthate (3836-23-5)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 24h; Ambient temperature;

Reference yield:

→ 17α-ethynyl-19-nortestosterone enanthate (3836-23-5)

Guidance literature:

Analog der vorangehenden Verbindung /0706489600004/;

Reference yield:

→ Heptanoic acid (10R,13S,17R)-17-ethynyl-13-methyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester (3836-23-5)

Guidance literature:

Keton VIII, H3C-(CH2)5-COCl, EtMgBr;

upstream raw materials:

oenanthic acid

17α-ethynyl-19-nortestosterone

Refernces