[7-Benzyloxy-4-(tert-butyldimethylsilanyloxy)-2-hydroxy-3,5-dimethylheptyl]phosphonic acid dimethyl ester

Base Information

Chemical Name:[7-Benzyloxy-4-(tert-butyldimethylsilanyloxy)-2-hydroxy-3,5-dimethylheptyl]phosphonic acid dimethyl ester
CAS No.:166322-62-9
Molecular Formula:C₂₄H₄₅O₆PSi
Molecular Weight:488.677
Hs Code.:

Synonyms:[7-Benzyloxy-4-(tert-butyldimethylsilanyloxy)-2-hydroxy-3,5-dimethylheptyl]phosphonic acid dimethyl ester

Suppliers and Price of [7-Benzyloxy-4-(tert-butyldimethylsilanyloxy)-2-hydroxy-3,5-dimethylheptyl]phosphonic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [7-Benzyloxy-4-(tert-butyldimethylsilanyloxy)-2-hydroxy-3,5-dimethylheptyl]phosphonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [7-Benzyloxy-4-(tert-butyldimethylsilanyloxy)-2-hydroxy-3,5-dimethylheptyl]phosphonic acid dimethyl ester

There total 14 articles about [7-Benzyloxy-4-(tert-butyldimethylsilanyloxy)-2-hydroxy-3,5-dimethylheptyl]phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 166322-61-8
6-Benzyloxy-3-(tert-butyldimethylsilanyloxy)-2,4-dimethylhexanal

: 756-79-6
dimethyl methane phosphonate

: 166322-62-9
[7-Benzyloxy-4-(tert-butyldimethylsilanyloxy)-2-hydroxy-3,5-dimethylheptyl]phosphonic acid dimethyl ester

Guidance literature:: dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

6-Benzyloxy-3-(tert-butyldimethylsilanyloxy)-2,4-dimethylhexanal; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Further stages.;
DOI:10.1039/b000751j

Reference yield:

: 4799-68-2
3-benzyloxypropan-1-ol

: 166322-62-9
[7-Benzyloxy-4-(tert-butyldimethylsilanyloxy)-2-hydroxy-3,5-dimethylheptyl]phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 14 steps

1.1: DMSO; oxalyl chloride; Et₃N / CH₂Cl₂ / 1 h / -78 °C

2.1: 28 g / CH₂Cl₂ / 20 °C

3.1: 84 percent / DIBAL-H / tetrahydrofuran; hexane / 2 h / 0 °C

4.1: (+)-diethyl tartrate; 4-Angstroem molecular sieves / Ti(OiPr)4 / CH₂Cl₂ / 0.5 h / -20 °C

4.2: 76 percent / t-BuOOH / CH₂Cl₂; 2,2,4-trimethyl-pentane / 20 h / -20 - -18 °C

5.1: CH₂Cl₂ / 15 h / 0 - 20 °C

6.1: aq. NaIO₄ / methanol / 6 h

7.1: 94 percent / CH₂Cl₂ / 20 °C

8.1: 96 percent / DIBAL-H / hexane; tetrahydrofuran / 2 h / 0 °C

9.1: (-)-diethyl tartrate; 4 Angstroem molecular sieves / Ti(i-OPr)4 / CH₂Cl₂ / 0.5 h / -20 °C

9.2: 85 percent / t-BuOOH / CH₂Cl₂ / 20 h / -20 - -18 °C

10.1: CuI / tetrahydrofuran / 0.5 h / 0 °C

10.2: tetrahydrofuran / 15 h / 5 °C

10.3: 84 percent / aq. NaIO₄ / methanol / 7 h

11.1: 97.5 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 - 20 °C

12.1: 96 percent / pyridinium toluene-p-sulfonate / CH₂Cl₂; methanol / 8 h / 20 °C

13.1: 96 percent / N-methylmorpholine N-oxide; 4 Angstroem molecular sieves / tetrapropyl ammonium perruthenate / CH₂Cl₂ / 1.25 h / 20 °C

14.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

14.2: 90 percent / hexane; tetrahydrofuran / 1 h / -78 °C

With 2,6-dimethylpyridine; sodium periodate; copper(l) iodide; n-butyllithium; oxalyl dichloride; 4 A molecular sieve; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; dimethyl sulfoxide; 4-methylmorpholine N-oxide; (+)-Weinsaeure-diethylester; (-)-diethyl tartrate; triethylamine; titanium(IV) isopropylate; tetrapropylammonium perruthennate; In tetrahydrofuran; methanol; hexane; dichloromethane; 1.1: Oxidation / 2.1: Condensation / 3.1: Reduction / 4.1: Substitution / 4.2: Epoxidation / 5.1: Methylation / 6.1: Oxidation / 7.1: Condensation / 8.1: Reduction / 9.1: Substitution / 9.2: Epoxidation / 10.1: Transmetallation / 10.2: Methylation / 10.3: Oxidation / 11.1: Substitution / 12.1: Substitution / 13.1: Oxidation / 14.1: Metallation / 14.2: Addition;
DOI:10.1039/b000751j

Reference yield:

: 70542-83-5
ethyl (2E)-5-(benzyloxy)pent-2-enoate

: 166322-62-9
[7-Benzyloxy-4-(tert-butyldimethylsilanyloxy)-2-hydroxy-3,5-dimethylheptyl]phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: 84 percent / DIBAL-H / tetrahydrofuran; hexane / 2 h / 0 °C

2.1: (+)-diethyl tartrate; 4-Angstroem molecular sieves / Ti(OiPr)4 / CH₂Cl₂ / 0.5 h / -20 °C

2.2: 76 percent / t-BuOOH / CH₂Cl₂; 2,2,4-trimethyl-pentane / 20 h / -20 - -18 °C

3.1: CH₂Cl₂ / 15 h / 0 - 20 °C

4.1: aq. NaIO₄ / methanol / 6 h

5.1: 94 percent / CH₂Cl₂ / 20 °C

6.1: 96 percent / DIBAL-H / hexane; tetrahydrofuran / 2 h / 0 °C

7.1: (-)-diethyl tartrate; 4 Angstroem molecular sieves / Ti(i-OPr)4 / CH₂Cl₂ / 0.5 h / -20 °C

7.2: 85 percent / t-BuOOH / CH₂Cl₂ / 20 h / -20 - -18 °C

8.1: CuI / tetrahydrofuran / 0.5 h / 0 °C

8.2: tetrahydrofuran / 15 h / 5 °C

8.3: 84 percent / aq. NaIO₄ / methanol / 7 h

9.1: 97.5 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / 0 - 20 °C

10.1: 96 percent / pyridinium toluene-p-sulfonate / CH₂Cl₂; methanol / 8 h / 20 °C

11.1: 96 percent / N-methylmorpholine N-oxide; 4 Angstroem molecular sieves / tetrapropyl ammonium perruthenate / CH₂Cl₂ / 1.25 h / 20 °C

12.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

12.2: 90 percent / hexane; tetrahydrofuran / 1 h / -78 °C

With 2,6-dimethylpyridine; sodium periodate; copper(l) iodide; n-butyllithium; 4 A molecular sieve; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; (+)-Weinsaeure-diethylester; (-)-diethyl tartrate; titanium(IV) isopropylate; tetrapropylammonium perruthennate; In tetrahydrofuran; methanol; hexane; dichloromethane; 1.1: Reduction / 2.1: Substitution / 2.2: Epoxidation / 3.1: Methylation / 4.1: Oxidation / 5.1: Condensation / 6.1: Reduction / 7.1: Substitution / 7.2: Epoxidation / 8.1: Transmetallation / 8.2: Methylation / 8.3: Oxidation / 9.1: Substitution / 10.1: Substitution / 11.1: Oxidation / 12.1: Metallation / 12.2: Addition;
DOI:10.1039/b000751j