N-[4-(aminosulfonyl)-2-methylphenyl]-2-[(6-cyano-1-(3,5-dimethylbenzoyl)-2-naphthalenyl)oxy]acetamide

Base Information

Chemical Name:N-[4-(aminosulfonyl)-2-methylphenyl]-2-[(6-cyano-1-(3,5-dimethylbenzoyl)-2-naphthalenyl)oxy]acetamide
CAS No.:1322667-75-3
Molecular Formula:C₂₉H₂₅N₃O₅S
Molecular Weight:527.601
Hs Code.:

Synonyms:N-[4-(aminosulfonyl)-2-methylphenyl]-2-[(6-cyano-1-(3,5-dimethylbenzoyl)-2-naphthalenyl)oxy]acetamide

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Chemical Property of N-[4-(aminosulfonyl)-2-methylphenyl]-2-[(6-cyano-1-(3,5-dimethylbenzoyl)-2-naphthalenyl)oxy]acetamide

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Technology Process of N-[4-(aminosulfonyl)-2-methylphenyl]-2-[(6-cyano-1-(3,5-dimethylbenzoyl)-2-naphthalenyl)oxy]acetamide

There total 4 articles about N-[4-(aminosulfonyl)-2-methylphenyl]-2-[(6-cyano-1-(3,5-dimethylbenzoyl)-2-naphthalenyl)oxy]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.2%

: 329944-57-2
N-[4-(aminosulfonyl)-2-methylphenyl]-2-bromoacetamide

: 1322667-94-6
C₂₀H₁₅NO₂

: 1322667-75-3
N-[4-(aminosulfonyl)-2-methylphenyl]-2-[(6-cyano-1-(3,5-dimethylbenzoyl)-2-naphthalenyl)oxy]acetamide

Guidance literature:: With potassium carbonate; sodium iodide; In acetone; for 2h; Reflux;
DOI:10.1016/j.bmc.2011.06.007

Reference yield:

: 1322667-86-6
C₁₉H₁₅BrO₂

: 1322667-75-3
N-[4-(aminosulfonyl)-2-methylphenyl]-2-[(6-cyano-1-(3,5-dimethylbenzoyl)-2-naphthalenyl)oxy]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 2 h / 160 °C

2: potassium carbonate; sodium iodide / acetone / 2 h / Reflux

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2011.06.007

Reference yield:

: 6613-44-1
3,5-dimethylbenzoyl chloride

: 1322667-75-3
N-[4-(aminosulfonyl)-2-methylphenyl]-2-[(6-cyano-1-(3,5-dimethylbenzoyl)-2-naphthalenyl)oxy]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride / carbon disulfide / 2 h / 5 °C / Reflux

1.2: 0.5 h / Cooling with ice

2.1: N,N-dimethyl-formamide / 2 h / 160 °C

3.1: potassium carbonate; sodium iodide / acetone / 2 h / Reflux

With aluminum (III) chloride; potassium carbonate; sodium iodide; In carbon disulfide; N,N-dimethyl-formamide; acetone; 1.1: Friedel-Crafts acylation;
DOI:10.1016/j.bmc.2011.06.007