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Technology Process of Aplaviroc

Aplaviroc

Base Information
  • Chemical Name:Aplaviroc
  • CAS No.:461443-59-4
  • Deprecated CAS:674782-28-6,675184-11-9
  • Molecular Formula:C33H43N3O6
  • Molecular Weight:577.71
  • Hs Code.:
  • UNII:98B425P30V
  • DSSTox Substance ID:DTXSID6047317
  • Nikkaji Number:J2.241.522K
  • Wikipedia:Aplaviroc
  • Wikidata:Q4779956
  • NCI Thesaurus Code:C78043
  • Pharos Ligand ID:5GNCSBAQYY24
  • Metabolomics Workbench ID:149807
  • ChEMBL ID:CHEMBL1255794
  • Mol file:461443-59-4.mol
Aplaviroc

Synonyms:4-((4-(((3R)-1-butyl-3-((R)-cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenyl)oxy)benzoic acid hydrochloride;aplaviroc;benzoic acid, 4-(4-(((3R)-1-butyl-3-((R)-cyclohexylhydroxymethyl)-2,5-dioxo-1,4,9- triazaspiro(55)undec-9-yl)methyl)phenoxy)-;GW873140;rac-4-(4-((1-butyl-3-(cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenoxy)benzoic acid

Suppliers and Price of Aplaviroc
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • American Custom Chemicals Corporation
  • APLAVIROC 95.00%
  • 5MG
  • $ 503.33
Total 15 raw suppliers
Chemical Property of Aplaviroc
Chemical Property:
  • Vapor Pressure:4.79E-27mmHg at 25°C 
  • Refractive Index:1.63 
  • Boiling Point:800.6°C at 760 mmHg 
  • PKA:4.29±0.10(Predicted) 
  • Flash Point:438°C 
  • PSA：119.41000 
  • Density:1.29g/cm3 
  • LogP:4.78460 
  • XLogP3:3.1
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:7
  • Rotatable Bond Count:10
  • Exact Mass:577.31518610
  • Heavy Atom Count:42
  • Complexity:915
Purity/Quality:

99% *data from raw suppliers

APLAVIROC 95.00% *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:
Useful:
  • Canonical SMILES:CCCCN1C(=O)C(NC(=O)C12CCN(CC2)CC3=CC=C(C=C3)OC4=CC=C(C=C4)C(=O)O)C(C5CCCCC5)O
  • Isomeric SMILES:CCCCN1C(=O)[C@H](NC(=O)C12CCN(CC2)CC3=CC=C(C=C3)OC4=CC=C(C=C4)C(=O)O)[C@@H](C5CCCCC5)O
  • Recent ClinicalTrials:Study Of Chemokine Coreceptor 5 (CCR5) Antagonist GW873140 In R5-Tropic Treatment-Experienced HIV-Infected Subjects
  • Recent EU Clinical Trials:A Phase III, randomized, double-blind, placebo-controlled, multicenter, parallel group study to compare the efficacy and safety of GW873140 400mg BID in combination with a ritonavir-containing optimized background therapy (OBT) regimen versus placebo plus OBT over 48 weeks in HIV-1 infected, treatment-experienced subjects with drug-resistant CCR5/CXCR4-tropic virus.
  • Uses Treatment of HIV infection.
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Total 8 Pictures about this product