(trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine

Base Information

Chemical Name:(trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine
CAS No.:356789-15-6
Molecular Formula:C₃₅H₄₇N₅O₉
Molecular Weight:681.786
Hs Code.:

Synonyms:(trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine

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Chemical Property of (trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine

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Technology Process of (trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine

There total 10 articles about (trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 356789-14-5
(trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine methyl ester

: 356789-15-6
(trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine

Guidance literature:: With sodium hydroxide; water; In ethanol; at 20 ℃;
DOI:10.1016/S0040-4020(01)00433-1

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 356789-15-6
(trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / Et₃N; BOP / dimethylformamide / 20 °C

2: 95 percent / HCl (g) / diethyl ether

3: 99 percent / Et₃N; BOP / dimethylformamide / 20 °C

4: HCl (g) / diethyl ether

5: 61.5 percent / Et₃N; BOP / dimethylformamide / 20 °C

6: 70 percent / NaOH; H₂O / ethanol / 20 °C

With hydrogenchloride; sodium hydroxide; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00433-1

Reference yield:

: 64152-76-7
methyl (S)-2-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropanamido)-4-methylpentanoate

: 356789-15-6
(trans)-N-(t-butoxycarbonyl)-L-tyrosylglycyl-N-(4-amino-1-oxo-2-butenyl)-L-phenylalanyl-L-leucine

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / HCl (g) / diethyl ether

2: 99 percent / Et₃N; BOP / dimethylformamide / 20 °C

3: HCl (g) / diethyl ether

4: 61.5 percent / Et₃N; BOP / dimethylformamide / 20 °C

5: 70 percent / NaOH; H₂O / ethanol / 20 °C

With hydrogenchloride; sodium hydroxide; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00433-1