1-benzyl-1H-imidazo[4,5-b]pyrazine

Base Information

• Chemical Name: 1-benzyl-1H-imidazo[4,5-b]pyrazine
• CAS No.: 1365094-36-5
• Molecular Formula: C₁₂H₁₀N₄
• Molecular Weight: 210.238
• Mol file: 1365094-36-5.mol

Synonyms:1-benzyl-1H-imidazo[4,5-b]pyrazine

Chemical Property of 1-benzyl-1H-imidazo[4,5-b]pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-1H-imidazo[4,5-b]pyrazine

There total 3 articles about 1-benzyl-1H-imidazo[4,5-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formamide (77287-34-4,77287-35-5,60100-09-6) + N-benzyl-3-chloropyrazin-2-amine → 1-benzyl-1H-imidazo[4,5-b]pyrazine (1365094-36-5)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; tert-Amyl alcohol; at 110 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1002/adsc.201400465

Reference yield:

N2-benzylpyrazine-2,3-diamine + orthoformic acid triethyl ester (122-51-0) → 1-benzyl-1H-imidazo[4,5-b]pyrazine (1365094-36-5)

Guidance literature:

With formic acid; In butan-1-ol; at 110 ℃;

DOI:10.1016/j.tetlet.2016.04.118

Reference yield:

benzylamine (100-46-9) → 1-benzyl-1H-imidazo[4,5-b]pyrazine (1365094-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere

2: potassium phosphate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; t-BuBrettPhos / tert-butyl alcohol / 0.5 h / 110 °C / Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium phosphate; t-BuBrettPhos; triethylamine; In 1,4-dioxane; tert-butyl alcohol;

DOI:10.1021/ol300359s

upstream raw materials:

formamide

benzylamine

orthoformic acid triethyl ester