4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde

Base Information

Chemical Name:4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde
CAS No.:1190236-05-5
Molecular Formula:C₁₇H₁₆F₃NO₃S
Molecular Weight:371.38
Hs Code.:

Synonyms:4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde

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Chemical Property of 4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde

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Technology Process of 4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde

There total 1 articles about 4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1190236-04-4
4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1190236-05-5
4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde

Guidance literature:: 4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 ℃; for 3h;

With water; In tetrahydrofuran; hexane;

Reference yield: 92.0%

: 1190236-05-5
4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde

: 1190236-06-6
4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yllmethanol

Guidance literature:: 4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[3-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde; With sodium tetrahydroborate; In tetrahydrofuran; ethanol; at 0 ℃; for 5h;

With water; In tetrahydrofuran; ethanol;