cis-1-benzylazetidine-2,4-dicarboxylic acid monobenzylester trifluoroacetate

Base Information

Chemical Name:cis-1-benzylazetidine-2,4-dicarboxylic acid monobenzylester trifluoroacetate
CAS No.:127310-62-7
Molecular Formula:C₂HF₃O₂*C₁₉H₁₉NO₄
Molecular Weight:439.388
Hs Code.:

Synonyms:cis-1-benzylazetidine-2,4-dicarboxylic acid monobenzylester trifluoroacetate

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Chemical Property of cis-1-benzylazetidine-2,4-dicarboxylic acid monobenzylester trifluoroacetate

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Technology Process of cis-1-benzylazetidine-2,4-dicarboxylic acid monobenzylester trifluoroacetate

There total 6 articles about cis-1-benzylazetidine-2,4-dicarboxylic acid monobenzylester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 121049-98-7,121049-99-8,127310-47-8,127310-48-9
cis-1-benzylazetidine-2,4-dicarboxylic acid benzyl tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 127310-62-7
cis-1-benzylazetidine-2,4-dicarboxylic acid monobenzylester trifluoroacetate

Guidance literature:: for 21h; Ambient temperature;
DOI:10.1021/jm00168a007

Reference yield:

: 121049-89-6
α,α'-dibromoglutaric anhydride

: 127310-62-7
cis-1-benzylazetidine-2,4-dicarboxylic acid monobenzylester trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1: CHCl₃ / 1.) RT, 1 h, 2.) reflux, 1 h

2: oxalyl chloride, DMF / CHCl₃; benzene / 1.) 0 deg C, 40 min, 2.) RT, 70 min

3: triethylamine, 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) RT, 20 min

4: 33 percent / dimethylformamide / 80 °C

5: 73 percent / 21 h / Ambient temperature

With dmap; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; chloroform; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00168a007

Reference yield:

: 2,4-Dibromo-4-chlorocarbonyl-butyric acid benzyl ester

: 127310-62-7
cis-1-benzylazetidine-2,4-dicarboxylic acid monobenzylester trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine, 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) RT, 20 min

2: 33 percent / dimethylformamide / 80 °C

3: 73 percent / 21 h / Ambient temperature

With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00168a007