Buflomedil hydrochloride

Base Information

• Chemical Name: Buflomedil hydrochloride
• CAS No.: 35543-24-9
• Molecular Formula: C17H25NO4^.HCl
• Molecular Weight: 343.851
• Hs Code.: 2933990090
• European Community (EC) Number: 252-611-9
• NSC Number: 759291
• UNII: 3J944AFS8S
• DSSTox Substance ID: DTXSID6046977
• Wikidata: Q27257293
• ChEMBL ID: CHEMBL1715107
• Mol file: 35543-24-9.mol

Synonyms:2,4,6-trimethoxyphenyl-3-pyrrolidine propyl ketone;blufomedil;Bufedil;Buflo 1A Pharma;Buflo AbZ;Buflo-POS;Buflo-Puren;Buflohexal;buflomedil;Buflomedil Heumann;buflomedil hydrochloride;Buflomedil Lindo;buflomedil pyridoxal phosphate;Buflomedil Stada;buflomedil von ct;Buflomedil-ratiopharm;bufomedil;Fonzylane;LL 1656;Lofton;Loftyl;Sinoxis

Chemical Property of Buflomedil hydrochloride

Chemical Property:

• Appearance/Colour: White or off-white crystalline powder
• Melting Point: 192-193°
• Boiling Point: 454.5 °C at 760 mmHg
• Flash Point: 228.7 °C
• PSA: 48.00000
• LogP: 3.51100
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Freely soluble in water, soluble in ethanol (96 per cent), very slightly soluble in acetone.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 8
• Exact Mass: 343.1550360
• Heavy Atom Count: 23
• Complexity: 330

Purity/Quality:

99.5% ^*data from raw suppliers

BuflomedilHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C(=C1)OC)C(=O)CCCN2CCCC2)OC.Cl
• Description: Buflomedil hydrochloride is a vasoactive drug with a variety of actions. It is an alpha-adrenoceptor antagonist and a weak calcium channel blocker. It inhibits platelet aggregation and improves erythrocyte deformability. However, its mechanism of action in peripheral vascular disease is not known.Buflomedil has generally been well tolerated by most patients in clinical trials. The most frequently reported adverse effects include flushing, headache, vertigo, gas-trointestinal discomfort, and dizziness. These rarely require drug withdrawal. In controlled trials, adverse effects have occurred in 20% of patients assigned to buflomedil and 18% of those assigned to placebo; only gastrointestinal discomfort occurred more frequently in buflomedil-treated patients (3.4 versus 2%)
• Uses: Buflomedil hydrochloride is a vasoactive agent. Its mode of action involves increasing the peripheral and cerebral blood flow in ischaemic tissues of patients, who are mostly affected with vascular diseases.Buflomedil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in peripheral and cerebral vascular diseases 1-[3-(2,4,6-Trimethoxybenzoyl)propyl]pyrrolidinium chloride is used as an vasodilator (peripheral).
• Therapeutic Function: Vasodilator

Technology Process of Buflomedil hydrochloride

There total 1 articles about Buflomedil hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3-trimethoxybenzene (621-23-8) + 4-(pyrrolidin-1-yl)butanoyl chloride (713069-87-5) → Buflomedil hydrochloride (35543-24-9)

Guidance literature:

1,2,3-trimethoxybenzene; 4-(pyrrolidin-1-yl)butanoyl chloride; With zinc(II) chloride; In dichloromethane; at 0 - 5 ℃; for 2h; Reflux;

With hydrogenchloride; In ethanol; at 60 - 70 ℃; for 1h;

upstream raw materials:

1,2,3-trimethoxybenzene

4-(pyrrolidin-1-yl)butanoyl chloride

Refernces