2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorobenzoic acid hydrochloride

Base Information

Chemical Name:2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorobenzoic acid hydrochloride
CAS No.:644970-11-6
Molecular Formula:C₂₂H₂₃ClFNO₅*ClH
Molecular Weight:472.341
Hs Code.:

Synonyms:2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorobenzoic acid hydrochloride

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Chemical Property of 2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorobenzoic acid hydrochloride

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Technology Process of 2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorobenzoic acid hydrochloride

There total 7 articles about 2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorobenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorobenzoate

: 644970-11-6
2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorobenzoic acid hydrochloride

Guidance literature:: methyl 2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorobenzoate; With potassium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 7h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃; pH=2.0;

Reference yield:

: 644970-09-2
methyl 4-fluoro-2-[(2S)-oxiran-2-ylmethoxy]benzoate

: 644970-11-6
2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorobenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 80 °C

2.1: potassium hydroxide / tetrahydrofuran; water / 7 h / 20 °C

2.2: 0 °C / pH 2.0

With potassium hydroxide; In tetrahydrofuran; ethanol; water;

Reference yield:

: 644967-79-3
5-chlorospiro[1-benzofuran-2,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester

: 644970-11-6
2-{[(2S)-3-(5-chloro-1'H,3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-fluorobenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / tetrahydrofuran / 22 h / 20 - 50 °C

2.1: ethanol / 80 °C

3.1: potassium hydroxide / tetrahydrofuran; water / 7 h / 20 °C

3.2: 0 °C / pH 2.0

With hydrogenchloride; potassium hydroxide; In tetrahydrofuran; ethanol; water;